β-肾上腺素能受体阻断可保留化学感受器对低氧的反应性。

beta-Adrenoceptor blockade spares chemoreceptor responsiveness to hypoxia.

作者信息

Gonsalves S F, Smith E J, Nolan W F, Dutton R E

出版信息

Brain Res. 1984 Dec 24;324(2):349-53. doi: 10.1016/0006-8993(84)90047-7.

Abstract

The effect of beta-adrenoceptor blockade on the carotid body chemoreceptor response to hypoxia was assessed in anesthetized and paralyzed cats. Propranolol, atenolol and ICI 118,551 each abolished the enhancement of chemoreceptor activity produced by i.v. infusion of exogenous isoproterenol; however, the blocking drugs did not significantly diminish the increase in chemoreceptor neural discharge induced by hypoxia. These results do not support the hypothesis that beta-adrenergic receptors play an essential role in the chemoreceptor response to oxygen deprivation.

摘要

在麻醉并瘫痪的猫身上评估了β-肾上腺素能受体阻断对颈动脉体化学感受器对缺氧反应的影响。普萘洛尔、阿替洛尔和ICI 118,551均消除了静脉输注外源性异丙肾上腺素所产生的化学感受器活动增强；然而，这些阻断药物并未显著减少缺氧诱导的化学感受器神经放电增加。这些结果不支持β-肾上腺素能受体在化学感受器对缺氧反应中起关键作用这一假说。