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The cleavage of DNA by type-I DNA topoisomerases.

作者信息

Kirkegaard K, Pflugfelder G, Wang J C

出版信息

Cold Spring Harb Symp Quant Biol. 1984;49:411-9. doi: 10.1101/sqb.1984.049.01.047.

DOI:10.1101/sqb.1984.049.01.047
PMID:6099250
Abstract
摘要

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1
The cleavage of DNA by type-I DNA topoisomerases.
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Modulation of the relaxing activity of Escherichia coli topoisomerase I by single-stranded DNA binding proteins.
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Archaebacterial reverse gyrase cleavage-site specificity is similar to that of eubacterial DNA topoisomerases I.古细菌反向回旋酶的切割位点特异性与真细菌DNA拓扑异构酶I的相似。
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Crystal structure of a complex of a type IA DNA topoisomerase with a single-stranded DNA molecule.IA型DNA拓扑异构酶与单链DNA分子复合物的晶体结构。
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Bacillus cereus DNA topoisomerase I and IIIalpha: purification, characterization and complementation of Escherichia coli TopoIII activity.蜡状芽孢杆菌DNA拓扑异构酶I和IIIα：大肠杆菌TopoIII活性的纯化、表征及互补作用
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Solution structure of the C-terminal single-stranded DNA-binding domain of Escherichia coli topoisomerase I.大肠杆菌拓扑异构酶I C端单链DNA结合结构域的溶液结构
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Ordered deletions using exonuclease III.使用核酸外切酶III进行定向缺失。
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Backbone dynamics of the C-terminal domain of Escherichia coli topoisomerase I in the absence and presence of single-stranded DNA.大肠杆菌拓扑异构酶I C末端结构域在单链DNA缺失和存在情况下的主链动力学
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Mechanistic study of E. coli DNA topoisomerase I: cleavage of oligonucleotides.大肠杆菌DNA拓扑异构酶I的机制研究：寡核苷酸的切割
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Interaction between transcribing RNA polymerase and topoisomerase I prevents R-loop formation in E. coli.转录 RNA 聚合酶与拓扑异构酶 I 之间的相互作用可防止 E. coli 中 R 环的形成。
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Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I.大肠杆菌拓扑异构酶I抑制超负DNA超螺旋的结构基础。
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The DNA relaxation activity and covalent complex accumulation of Mycobacterium tuberculosis topoisomerase I can be assayed in Escherichia coli: application for identification of potential FRET-dye labeling sites.
结核分枝杆菌拓扑异构酶 I 的 DNA 松弛活性和共价复合物积累可在大肠杆菌中进行检测：用于鉴定潜在荧光共振能量转移染料标记位点的应用。
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Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I.活性位点酪氨酸附近的突变可增强细菌拓扑异构酶I的TOPRIM甘氨酸至丝氨酸突变体的DNA切割和细胞杀伤作用。
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