切割单链或双链DNA的拓扑异构酶之间的结构相似性。
Structural similarities between topoisomerases that cleave one or both DNA strands.
作者信息
Berger J M, Fass D, Wang J C, Harrison S C
机构信息
Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7876-81. doi: 10.1073/pnas.95.14.7876.
Abstract
Type IA and type II DNA topoisomerases are distinguished by their ability to cleave one or two strands, respectively, of a DNA duplex. Both types have been proposed to use an "enzyme-bridging" mechanism, in which a break is formed in a DNA strand and a gap is opened between the broken pieces to allow passage of a second DNA strand or duplex segment. Although the type IA and type II topoisomerase structures appear overall quite different from one another, unexpected similarities between several structural elements suggest that members of the two subfamilies may use comparable mechanisms to bind and cleave DNA.
摘要
IA型和II型DNA拓扑异构酶的区别在于它们分别切割DNA双链中的一条链或两条链的能力。两种类型的酶都被认为使用一种“酶桥接”机制，即在DNA链中形成一个断裂，并在断裂片段之间打开一个缺口，以使第二条DNA链或双链片段通过。尽管IA型和II型拓扑异构酶的结构总体上看起来彼此非常不同，但几个结构元件之间意外的相似性表明，这两个亚家族的成员可能使用类似的机制来结合和切割DNA。
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