Traynor J R, Rance M J
Neuropeptides. 1984 Dec;5(1-3):81-4. doi: 10.1016/0143-4179(84)90032-5.
The presence of binding sites for ligands of mu and delta, in addition to kappa selectivity, have been demonstrated in the lumbo-sacral spinal cord of the rat by direct binding of [3H]ligands. These findings have been confirmed by competition studies. This information helps explain the observed pharmacology of opioids after intrathecal administration.
通过[3H]配体的直接结合，已在大鼠腰骶脊髓中证实除了κ选择性外，还存在μ和δ配体的结合位点。这些发现已通过竞争研究得到证实。这些信息有助于解释鞘内给药后观察到的阿片类药物药理学。
