Morris B J, Herz A
Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, Federal Republic of Germany.
Naunyn Schmiedebergs Arch Pharmacol. 1987 Aug;336(2):240-3. doi: 10.1007/BF00165811.
The distribution of opiate binding sites was studied in sections of rat lumbar spinal cord under conditions selective for mu, delta and kappa receptors. While the levels of mu binding sites were highest in the substantia gelatinosa, elevated levels were also observed in laminae III, IV, V and VIII. In contrast, delta binding was notable only in lamina I. The levels of typical kappa sites were low, and were concentrated in the substantia gelatinosa. An additional, atypical site was detected using 3H-diprenorphine in the presence of mu, delta and kappa receptor blocking agents, and this site was also concentrated in the substantia gelatinosa.
在对μ、δ和κ受体具有选择性的条件下，研究了大鼠腰段脊髓切片中阿片类结合位点的分布。虽然μ结合位点的水平在胶状质中最高，但在Ⅲ、Ⅳ、Ⅴ和Ⅷ层也观察到其水平升高。相比之下，δ结合仅在Ⅰ层显著。典型κ位点的水平较低，且集中在胶状质中。在存在μ、δ和κ受体阻断剂的情况下，使用3H-二丙诺啡检测到一个额外的非典型位点，该位点也集中在胶状质中。
