Gibson C F, Donaldson A I, Ferris N P
Vaccine. 1984 Jun;2(2):157-61. doi: 10.1016/0264-410x(84)90008-2.
Administration of three-fold or six-fold larger doses of conventional monovalent type O foot and mouth disease (FMD) vaccine to sheep prevented viraemic distribution of virus after exposure to airborne virus one week later. However, virus replication in the respiratory tract or excretion in oesophageal-pharyngeal fluids and breath was not prevented. The implication of these findings for the use of vaccine as an adjunct to a 'stamping out' policy for countries which are free from FMD and which do not practice mass annual vaccination are discussed.
给绵羊接种三倍或六倍剂量的传统单价O型口蹄疫（FMD）疫苗，可防止其在一周后接触空气传播病毒后出现病毒血症性病毒分布。然而，呼吸道中的病毒复制或食管-咽部分泌物及呼出气体中的病毒排泄并未得到阻止。本文讨论了这些研究结果对于在无口蹄疫且不实行大规模年度疫苗接种的国家将疫苗用作“扑杀”政策辅助手段的意义。
