依那普利治疗心力衰竭
Enalapril in heart failure.
作者信息
Nicholls M G, Ikram H, Espiner E A, Webster M W, Fitzpatrick M A
出版信息
Br J Clin Pharmacol. 1984;18 Suppl 2(Suppl 2):163S-167S. doi: 10.1111/j.1365-2125.1984.tb02594.x.
Abstract
Serum MK-422 and plasma angiotensin converting enzyme activity were measured during the introduction of enalapril therapy in eight patients with heart failure. In a second study of 16 patients, we recorded exercise tolerance, clinical status and haemodynamics before and after 12 weeks of placebo or enalapril treatment. Increasing doses of enalapril gave step-wise increments in serum MK-422. Plasma converting enzyme activity remained low for at least 24 h after each dose of enalapril (5, 10 and 20 mg). Compared to placebo patients (n = 8), those receiving enalapril (n = 8) tended to improve their exercise performance and clinical status, and showed a fall in right heart pressures after 12 weeks of treatment.
摘要
在对8例心力衰竭患者引入依那普利治疗期间，测定了血清MK - 422和血浆血管紧张素转换酶活性。在另一项针对16例患者的研究中，我们记录了安慰剂或依那普利治疗12周前后的运动耐量、临床状况和血流动力学。依那普利剂量增加时，血清MK - 422呈逐步上升。每次给予依那普利（5、10和20毫克）后，血浆转换酶活性至少在24小时内保持较低水平。与接受安慰剂的患者（n = 8）相比，接受依那普利的患者（n = 8）在治疗12周后运动表现和临床状况趋于改善，右心压力下降。
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