保钾利尿剂对心力衰竭患者肾素-血管紧张素-醛固酮系统及钾潴留的影响
Effect of potassium-sparing diuretics on the renin-angiotensin-aldosterone system and potassium retention in heart failure.
作者信息
Nicholls M G, Espiner E A, Hughes H, Rogers T
出版信息
Br Heart J. 1976 Oct;38(10):1025-30. doi: 10.1136/hrt.38.10.1025.
Abstract
The renin-angiotensin-aldosterone system and electrolyte levels in 11 patients with heart failure controlled on digoxin and frusemide were investigated after separate periods of Slow K, spironolactone, and amiloride therapy. When spironolactone or amiloride replaced Slow K, distinct parallel increments in the levels of renin, angiotensin II, and aldosterone resulted. Though plasma potassium was generally higher after spironolactone and amiloride than after Slow K, exchangeable potassium was similar with the three regimens. There was no significant relation between plasma potassium and concurrent exchangeable potassium.
摘要
在分别进行慢钾、螺内酯和氨氯吡咪治疗的不同阶段后，对11例用地高辛和速尿控制心力衰竭的患者的肾素 - 血管紧张素 - 醛固酮系统及电解质水平进行了研究。当螺内酯或氨氯吡咪替代慢钾时，肾素、血管紧张素II和醛固酮水平出现明显的平行升高。虽然螺内酯和氨氯吡咪治疗后的血浆钾一般高于慢钾治疗后，但三种治疗方案的可交换钾相似。血浆钾与同时期的可交换钾之间无显著关系。
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