Abraham A D
Mol Cell Biochem. 1975 Dec 31;9(3):131-3. doi: 10.1007/BF01751307.
Hydrocortisone hemisuccinate within 4 hours after in vivo administration produced an increase in precursor incoporation into rat thymus RNA and proteins in the whole animal. From these results, together with information obtained from measurements of the tyrosine aminotransferase activity and the action of mitomycin C administered one hour before the injection of hydrocortisone, it can be concluded that the increase in tissue level of the enzyme, consequent to hydrocortisone treatment, results from an increased rate of biosynthesis of the enzyme, which participates in the catabolic processes of proteins in glucocorticoid sensitive thymus cells.
氢化可的松半琥珀酸酯在体内给药后4小时内，使整个动物体内前体掺入大鼠胸腺RNA和蛋白质的量增加。根据这些结果，以及从酪氨酸转氨酶活性测量和在注射氢化可的松前一小时给予丝裂霉素C的作用所获得的信息，可以得出结论，氢化可的松治疗后酶的组织水平升高是由于酶生物合成速率增加所致，该酶参与糖皮质激素敏感胸腺细胞中蛋白质的分解代谢过程。
