Yabuuchi H, Baba K, Tsuda N, Okada S, Nose O, Seino Y, Tomita K, Ha K, Mimaki T, Ogawa M
Biken J. 1984 Sep;27(2-3):43-9.
A total of 663 children with various underlying diseases were immunized with a live varicella vaccine at the vaccine clinic of Osaka University Hospital during a period of seven years from October, 1975. Clinical reactions after vaccination occurred in 32.4% (24/74) of the children with malignancies and in 0.3% (2/591) of those in other groups. Vaccine-induced immunity was detected for more than 6 years, by FAMA (fluorescent antibody to membrane antigen) and IAHA (immune adherence hemagglutination) tests, and a skin-test for varicella-zoster virus (VZV). During an observation period of more than 7 years, clinical varicella developed in 12 children, 8 of whom were in the group with malignancies. Zoster occurred in only 4 (9.1%) of 44 vaccinees with acute leukemia, this incidence being significantly less (p less than 0.05) than that (21.6%, 8/37) in un-vaccinated leukemic children.
1975年10月至七年间，大阪大学医院疫苗门诊共为663名患有各种基础疾病的儿童接种了水痘活疫苗。接种后，恶性肿瘤患儿中有32.4%（24/74）出现临床反应，其他组患儿中有0.3%（2/591）出现临床反应。通过荧光膜抗原抗体（FAMA）、免疫黏附血凝试验（IAHA）以及水痘-带状疱疹病毒（VZV）皮肤试验检测到疫苗诱导的免疫力持续超过6年。在超过7年的观察期内，12名儿童发生了临床水痘，其中8名在恶性肿瘤组。44名急性白血病疫苗接种者中仅4人（9.1%）发生带状疱疹，这一发生率显著低于未接种疫苗的白血病儿童（21.6%，8/37）（p<0.05）。
