Asano Y, Albrecht P, Vujcic L K, Quinnan G V, Kawakami K, Takahashi M
Pediatrics. 1983 Sep;72(3):291-4.
Twenty-six healthy children susceptible to varicella were inoculated with the OKA strain of live attenuated varicella vaccine. All of the recipients showed good antibody responses without adverse clinical reactions. The seropositivity rate 5 years after vaccination was 100% by the enhanced neutralization test and 96% by the fluorescent antibody membrane antigen (FAMA) test. None of the recipients contracted varicella in spite of documented contact exposure. None of the children developed herpes zoster during the 5-year observation period. The results suggest that attenuated varicella vaccine has long-term protective efficacy.
26名对水痘易感的健康儿童接种了OKA株减毒活水痘疫苗。所有接种者均表现出良好的抗体反应，且无不良临床反应。接种疫苗5年后，通过增强中和试验检测的血清阳性率为100%，通过荧光抗体膜抗原（FAMA）试验检测的血清阳性率为96%。尽管有明确的接触暴露史，但所有接种者均未感染水痘。在5年观察期内，所有儿童均未发生带状疱疹。结果表明，减毒水痘疫苗具有长期保护效力。
