双硫仑神经病变中的丝状轴索性神经病

Filamentous axonopathy in disulfiram neuropathy.

作者信息

Bilbao J M, Briggs S J, Gray T A

出版信息

Ultrastruct Pathol. 1984;7(4):295-300. doi: 10.3109/01913128409141490.

DOI:10.3109/01913128409141490

Abstract

A 52-year-old female developed a sensorimotor polyneuropathy while on treatment with disulfiram. Electron microscopic examination of a sural nerve biopsy disclosed occasional axons distended by intermediate filaments. Identical changes can be induced in animals by carbon disulfide (CS2), a metabolite of disulfiram. Our findings suggest that disulfiram neurotoxicity is mediated by CS2 and is exerted on the distal axon.

摘要

一名52岁女性在接受双硫仑治疗时出现感觉运动性多发性神经病。对腓肠神经活检进行电子显微镜检查发现，偶尔有轴突被中间丝扩张。双硫仑的代谢产物二硫化碳（CS2）可在动物身上诱发相同的变化。我们的研究结果表明，双硫仑神经毒性是由CS2介导的，并且作用于远端轴突。