有和无肾功能不全的人体中头孢唑肟的消除动力学。
Elimination kinetics of ceftizoxime in humans with and without renal insufficiency.
作者信息
Ohkawa M, Okasho A, Sugata T, Kuroda K
出版信息
Antimicrob Agents Chemother. 1982 Aug;22(2):308-11. doi: 10.1128/AAC.22.2.308.
Abstract
The pharmacokinetics of a single 500-mg intramuscular dose of ceftizoxime were studied in 11 healthy adult volunteers and in 22 patients with various degrees of renal dysfunction. The mean serum half-life of ceftizoxime was 1.44 h in normal subjects and 30.2 h in hemodialysis patients. A significant correlation (P less than 0.001) between the elimination rate constant of ceftizoxime and creatinine clearance was demonstrated. The mean urinary recovery in normal subjects was 75.6% within 6 h of dosage; recovery decreased progressively with reduced renal function.
摘要
在11名健康成年志愿者和22名不同程度肾功能不全的患者中研究了单次肌内注射500毫克头孢唑肟的药代动力学。头孢唑肟在正常受试者中的平均血清半衰期为1.44小时，在血液透析患者中为30.2小时。头孢唑肟的消除速率常数与肌酐清除率之间存在显著相关性（P小于0.001）。正常受试者在给药后6小时内的平均尿回收率为75.6%；随着肾功能下降，回收率逐渐降低。
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4
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