头孢唑肟（一种对β-内酰胺酶稳定的头孢菌素）的抗菌活性
Antibacterial activity of ceftizoxime, a beta-lactamase-stable cephalosporin.
作者信息
Fu K P, Neu H C
出版信息
Antimicrob Agents Chemother. 1980 Apr;17(4):583-90. doi: 10.1128/AAC.17.4.583.
Abstract
The in vitro activity of ceftizoxime was compared with that of other beta-lactam antibiotics against 538 isolates. Ceftizoxime was the most active agent tested against Escherichia coli and Klebsiella, inhibiting 80% at 0.025 microgram/ml. It was more active than cefotaxime against Enterobacter cloacae and E. aerogenes. Ceftizoxime was more active than cefoxitin, cefotaxime, cefoperazone, and carbenicillin against Proteus mirabilis and indole-positive Proteus. It inhibited 97% of multiresistant Serratia isolates at 12.5 microgram/ml, whereas cefotaxime inhibited only 19%. Ceftizoxime was less active than cefotaxime and cefoperazone against Pseudomonas aeruginosa, but was more active than carbenicillin. It was more active than cefotaxime and cefoxitin against Bacteroides. It was not appreciably destroyed by beta-lactamases of Staphylococcus aureus, Enterobacteriaceae, or Pseudomonas.
摘要
将头孢唑肟的体外活性与其他β-内酰胺类抗生素针对538株分离菌的活性进行了比较。头孢唑肟是针对大肠杆菌和克雷伯菌测试的最具活性的药物，在0.025微克/毫升时抑制率达80%。它对阴沟肠杆菌和气杆菌的活性比头孢噻肟更强。头孢唑肟对奇异变形杆菌和吲哚阳性变形杆菌的活性比头孢西丁、头孢噻肟、头孢哌酮和羧苄西林更强。它在12.5微克/毫升时能抑制97%的多重耐药沙雷菌分离株，而头孢噻肟仅能抑制19%。头孢唑肟对铜绿假单胞菌的活性比头孢噻肟和头孢哌酮弱，但比羧苄西林强。它对拟杆菌的活性比头孢噻肟和头孢西丁更强。它不会被金黄色葡萄球菌、肠杆菌科细菌或假单胞菌的β-内酰胺酶显著破坏。
相似文献
1
Antibacterial activity of ceftizoxime, a beta-lactamase-stable cephalosporin.头孢唑肟（一种对β-内酰胺酶稳定的头孢菌素）的抗菌活性
Antimicrob Agents Chemother. 1980 Apr;17(4):583-90. doi: 10.1128/AAC.17.4.583.
2
In vitro activity and beta-lactamase stability of cefmenoxime.头孢甲肟的体外活性及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1982 Aug;22(2):316-22. doi: 10.1128/AAC.22.2.316.
3
Antibacterial activity of ceftriaxone (Ro 13-9904), a beta-lactamase-stable cephalosporin.头孢曲松（Ro 13 - 9904）的抗菌活性，一种对β-内酰胺酶稳定的头孢菌素。
Antimicrob Agents Chemother. 1981 Mar;19(3):414-23. doi: 10.1128/AAC.19.3.414.
4
The activity and beta-lactamase stability of cefotetan compared to other beta-lactam antibiotics.与其他β-内酰胺类抗生素相比，头孢替坦的活性及β-内酰胺酶稳定性。
Chemioterapia. 1985 Aug;4(4):271-7.
5
In vitro antimicrobial activity of cefotaxime, a new cephalosporin.新型头孢菌素头孢噻肟的体外抗菌活性
Antimicrob Agents Chemother. 1980 Jul;18(1):1-8. doi: 10.1128/AAC.18.1.1.
6
In vitro antibacterial activity and beta-lactamase stability of E-0702, a new cephalosporin.新型头孢菌素E-0702的体外抗菌活性及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1983 Sep;24(3):313-20. doi: 10.1128/AAC.24.3.313.
7
Comparative activity and beta-lactamase stability of cefoperazone, a piperazine cephalosporin.哌嗪头孢菌素头孢哌酮的比较活性及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1979 Aug;16(2):150-7. doi: 10.1128/AAC.16.2.150.
8
Antibacterial activity and beta-lactamase stability of ceftazidime, an aminothiazolyl cephalosporin potentially active against Pseudomonas aeruginosa.头孢他啶的抗菌活性及β-内酰胺酶稳定性，一种对铜绿假单胞菌可能具有活性的氨噻唑基头孢菌素。
Antimicrob Agents Chemother. 1982 Jan;21(1):11-8. doi: 10.1128/AAC.21.1.11.
9
In vitro antibacterial activity of ceftizoxime against gram-negative strains.
Chemioterapia. 1985 Apr;4(2):166-9.
引用本文的文献
1
PEGylated Silk Fibroin Nanoparticles for Oral Antibiotic Delivery: Insights into Drug-Carrier Interactions and Process Greenness.用于口服抗生素递送的聚乙二醇化丝素蛋白纳米颗粒：对药物-载体相互作用及过程绿色度的洞察
ACS Omega. 2025 Mar 14;10(11):11627-11641. doi: 10.1021/acsomega.5c01089. eCollection 2025 Mar 25.
2
The Chemical Relationship Among Beta-Lactam Antibiotics and Potential Impacts on Reactivity and Decomposition.β-内酰胺类抗生素之间的化学关系及其对反应活性和分解的潜在影响。
Front Microbiol. 2022 Mar 24;13:807955. doi: 10.3389/fmicb.2022.807955. eCollection 2022.
3
FDA-Approved Oximes and Their Significance in Medicinal Chemistry.美国食品药品监督管理局批准的肟类化合物及其在药物化学中的意义。
Pharmaceuticals (Basel). 2022 Jan 4;15(1):66. doi: 10.3390/ph15010066.
4
A retrospective analysis of pharmacokinetic-pharmacodynamic parameters as indicators of the clinical efficacy of ceftizoxime.头孢唑肟临床疗效指标的药代动力学-药效学参数回顾性分析
Clin Pharmacokinet. 2001;40(2):125-34. doi: 10.2165/00003088-200140020-00004.
5
The antimicrobial activity of cefotaxime: comparative multinational hospital isolate surveys covering 15 years.头孢噻肟的抗菌活性：涵盖15年的多国医院分离株比较调查
Infection. 1994;22 Suppl 3:S152-60. doi: 10.1007/BF01782700.
6
Sensitivity of 341 non-fermentative gram-negative bacteria to seven beta-lactam antibiotics.341株非发酵革兰阴性菌对七种β-内酰胺类抗生素的敏感性
Eur J Clin Microbiol. 1982 Jun;1(3):159-65. doi: 10.1007/BF02019617.
7
Comparative activities of 13 beta-lactam antibiotics.13种β-内酰胺类抗生素的比较活性
Antimicrob Agents Chemother. 1982 Jun;21(6):925-34. doi: 10.1128/AAC.21.6.925.
8
beta-Lactam resistance in Serratia marcescens: comparison of action of benzylpenicillin, Apalcillin, Cefazolin, and ceftizoxime.粘质沙雷氏菌对β-内酰胺类抗生素的耐药性：苄青霉素、阿帕西林、头孢唑林和头孢唑肟的作用比较。
Antimicrob Agents Chemother. 1981 Mar;19(3):397-401. doi: 10.1128/AAC.19.3.397.
9
Antibacterial activity of ceftriaxone (Ro 13-9904), a beta-lactamase-stable cephalosporin.头孢曲松（Ro 13 - 9904）的抗菌活性，一种对β-内酰胺酶稳定的头孢菌素。
Antimicrob Agents Chemother. 1981 Mar;19(3):414-23. doi: 10.1128/AAC.19.3.414.
10
[N-formimidoyl-thienamycin: in vitro activity in bacteria with resistance to beta-lactam antibiotics or gentamicin].[N-甲脒基硫霉素：对β-内酰胺类抗生素或庆大霉素耐药细菌的体外活性]
Infection. 1982 Nov-Dec;10(6):361-70. doi: 10.1007/BF01642300.
本文引用的文献
1
Cefamandole, a cephalosporin antibiotic with an unusually wide spectrum of activity.头孢孟多，一种具有异常广泛活性谱的头孢菌素抗生素。
Antimicrob Agents Chemother. 1974 Aug;6(2):177-82. doi: 10.1128/AAC.6.2.177.
2
Cefoxitin, a semisynthetic cephamycin antibiotic: antibacterial spectrum and resistance to hydrolysis by gram-negative beta-lactamases.头孢西丁，一种半合成头孢霉素抗生素：抗菌谱及对革兰氏阴性β-内酰胺酶水解的抗性。
Antimicrob Agents Chemother. 1974 Aug;6(2):170-6. doi: 10.1128/AAC.6.2.170.
3
Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.一种使用显色头孢菌素底物检测β-内酰胺酶的新方法。
Antimicrob Agents Chemother. 1972 Apr;1(4):283-8. doi: 10.1128/AAC.1.4.283.
4
Cefoxitin resistance to beta-lactamase: a major factor for susceptibility of bacteroides fragilis to the antibiotic.头孢西丁对β-内酰胺酶的耐药性：脆弱拟杆菌对抗生素敏感性的一个主要因素。
Antimicrob Agents Chemother. 1977 Apr;11(4):725-34. doi: 10.1128/AAC.11.4.725.
5
HR 756, a new cephalosporin active against gram-positive and gram-negative aerobic and anaerobic bacteria.HR 756，一种对革兰氏阳性菌及革兰氏阴性需氧菌和厌氧菌均有活性的新型头孢菌素。
Antimicrob Agents Chemother. 1979 Feb;15(2):273-81. doi: 10.1128/AAC.15.2.273.
6
Studies on gonococcus infection. XI. Comparison of in vivo and vitro association of Neisseria gonorrhoeae with human neutrophils.淋病奈瑟菌感染的研究。十一。淋病奈瑟菌在体内和体外与人中性粒细胞结合的比较。
J Infect Dis. 1978 Jan;137(1):38-43. doi: 10.1093/infdis/137.1.38.
7
Comparative activity and beta-lactamase stability of cefoperazone, a piperazine cephalosporin.哌嗪头孢菌素头孢哌酮的比较活性及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1979 Aug;16(2):150-7. doi: 10.1128/AAC.16.2.150.
8
beta-lactamase stability of HR 756, a novel cephalosporin, compared to that of cefuroxime and cefoxitin.新型头孢菌素HR 756与头孢呋辛和头孢西丁相比的β-内酰胺酶稳定性。
Antimicrob Agents Chemother. 1978 Sep;14(3):322-6. doi: 10.1128/AAC.14.3.322.
Zotero 插件