依替卡因在人体中的循环代谢产物。
Cyclic metabolites of etidocaine in humans.
作者信息
Morgan D J, Smyth M P, Thomas J, Vine J
出版信息
Xenobiotica. 1977 Jun;7(6):365-75. doi: 10.3109/00498257709035795.
PMID:610053
Abstract
- Three cyclic metabolites of etidocaine excreted in urine of man have been investigated by g.l.c.-mass spectrometry. 2. These metabolites have been identified as 3-(2,6-dimethylphenyl)-5-ethyl-2,4-imidazolidinedione, 1-(2,6-dimethylphenyl)-2-methyl-4-ethyl-2-imidazolin-5-one and 1-(2,6-dimethylphenyl)-2,4-diethyl-2-imidazoline-5-one. 3. Formation in vivo of two of the metabolites is proposed to proceed via carbinolamine intermediates.
摘要
- 已通过气相色谱 - 质谱联用技术对人体尿液中排泄的依替卡因的三种环状代谢物进行了研究。2. 这些代谢物已被鉴定为3 - (2,6 - 二甲基苯基)-5 - 乙基 - 2,4 - 咪唑烷二酮、1 - (2,6 - 二甲基苯基)-2 - 甲基 - 4 - 乙基 - 2 - 咪唑啉 - 5 - 酮和1 - (2,6 - 二甲基苯基)-2,4 - 二乙基 - 2 - 咪唑啉 - 5 - 酮。3. 其中两种代谢物在体内的形成过程被认为是通过氨基醇中间体进行的。
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