Abdel-Salam A R, Vonwiller J B, Scott D B
Br J Anaesth. 1975 Oct;47(10):1081-6. doi: 10.1093/bja/47.10.1081.
Etidocaine has been evaluated in extradural block with regard to its absorption, toxicity and clinical effectiveness, which have been compared with those of bupivacaine. Etidocaine is associated with lower plasma concentrations than bupivacaine and its absorption is decreased by the addition of adrenaline 1:200,000 to a greater extent than is the case with bupivacaine. Etidocaine causes motor paralysis more frequently than does bupivacaine, especially if adrenaline is added. The duration of action of the two drugs is similar when comparing etidocaine 1% and bupivacaine 0.5%. Bupivacaine 0.75%, however, acts for a significantly longer time than etidocaine 1%. The drug is a useful addition to the range of local anaesthetics, especially with regard to the degree of motor blockade it can achieve during surgical procedures.
已对依替卡因在硬膜外阻滞中的吸收、毒性和临床疗效进行了评估，并与布比卡因的这些特性进行了比较。与布比卡因相比，依替卡因的血浆浓度较低，并且加入1:200,000的肾上腺素后，其吸收减少的程度比布比卡因更大。依替卡因比布比卡因更常引起运动麻痹，尤其是在加入肾上腺素的情况下。比较1%依替卡因和0.5%布比卡因时，两种药物的作用持续时间相似。然而，0.75%布比卡因的作用时间明显长于1%依替卡因。该药物是局部麻醉药系列中的一种有用补充，特别是在手术过程中它所能达到的运动阻滞程度方面。
