接受甲氨蝶呤、依那西普和利妥昔单抗（MER）治疗患者的肺部肉芽肿

Pulmonary granulomas in a patient on MER therapy.

作者信息

Lundy J, Damjanov I, Ballow M, Henken M, Mitchell M S

出版信息

Yale J Biol Med. 1977 Nov-Dec;50(6):665-8.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2595565/

Abstract

A patient with metastatic melanoma developed symmetric miliary infiltrates of the lungs while receiving injections of MER into tumor containing lymph nodes of the groin. Open lung biopsy identified the pulmonary lesions as caseating epithelioid granulomas. After cessation of MER therapy, the pulmonary lesions regressed spontaneously. The possible etiology of this so-far-unreported complication of MER therapy was briefly discussed.

摘要

一名转移性黑色素瘤患者在接受将MER注射入腹股沟含肿瘤淋巴结的治疗过程中，肺部出现了对称性粟粒状浸润。开放性肺活检将肺部病变确定为干酪样上皮样肉芽肿。停止MER治疗后，肺部病变自行消退。本文简要讨论了这种MER治疗迄今未报告并发症的可能病因。