Quesada J R, Libshitz H I, Hersh E M, Gutterman J U
Cancer. 1980 Mar 15;45(6):1340-3. doi: 10.1002/1097-0142(19800315)45:6<1340::aid-cncr2820450612>3.0.co;2-7.
Eight of 64 patients receiving intravenous administration of methanol extraction residue (MER) of Bacillus Calmette-Guerin (BCG), developed miliary-type pulmonary parenchymal changes. The clinical and radiological characteristics are described. An increased incidence was noted in patients with a history of previous BCG exposure or with positive PPD skin reactivity. Spontaneous resolution was observed upon discontinuation of MER. These changes most likely respresent a granulomatous inflammatory process, although no histological confirmation was obtained.
64名接受卡介苗（BCG）甲醇提取残渣（MER）静脉注射的患者中有8人出现粟粒型肺实质改变。描述了其临床和放射学特征。既往有卡介苗接触史或PPD皮肤反应呈阳性的患者发病率增加。停用MER后观察到病变自发消退。尽管未获得组织学证实，但这些改变很可能代表一种肉芽肿性炎症过程。
