艾滋病脑病患者大脑中的人类嗜T淋巴细胞病毒III型/淋巴腺病相关病毒样逆转录病毒颗粒。

HTLV-III/LAV-like retrovirus particles in the brains of patients with AIDS encephalopathy.

作者信息

Epstein L G, Sharer L R, Cho E S, Myenhofer M, Navia B, Price R W

出版信息

AIDS Res. 1984;1(6):447-54. doi: 10.1089/aid.1.1983.1.447.

DOI:10.1089/aid.1.1983.1.447

Abstract

It has been postulated that the retrovirus HTLV-III/LAV thought to be the etiologic agent of AIDS also infects the central nervous system and directly causes AIDS encephalopathy. Electron microscopical studies performed on brain sections from three patients with AIDS complicated by progressive encephalopathy revealed structures morphologically consistent with HTLV-III/LAV retrovirus particles. The particles were located principally within multinucleated giant cells but were also present in astrocytes. Many particles were also noted in the extracellular space.

摘要

据推测，被认为是艾滋病病因的逆转录病毒HTLV-III/LAV也感染中枢神经系统并直接导致艾滋病脑病。对三名患有艾滋病并伴有进行性脑病的患者的脑切片进行的电子显微镜研究显示，其结构在形态上与HTLV-III/LAV逆转录病毒颗粒一致。这些颗粒主要位于多核巨细胞内，但也存在于星形胶质细胞中。在细胞外空间也发现了许多颗粒。