Koenig S, Gendelman H E, Orenstein J M, Dal Canto M C, Pezeshkpour G H, Yungbluth M, Janotta F, Aksamit A, Martin M A, Fauci A S
Science. 1986 Sep 5;233(4768):1089-93. doi: 10.1126/science.3016903.
One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.
获得性免疫缺陷综合征（艾滋病）患者常见的神经并发症之一是伴有进行性痴呆的亚急性脑病。通过使用病毒分离共培养、原位杂交、免疫细胞化学和透射电子显微镜技术，在两名受影响个体中确定了一种支持艾滋病逆转录病毒在脑组织中复制的重要细胞类型的身份。这些细胞是单核和多核巨噬细胞，它们在患者大脑中积极合成病毒RNA并产生子代病毒颗粒。受感染的脑巨噬细胞可能作为病毒的储存库，并作为病毒在受感染宿主中传播的载体。
