Moszczyński P, Lisiewicz J
Rev Esp Oncol. 1984;31(3):435-41.
Histochemical studies of peripheral blood neutrophils have been performed in 106 workers occupationally exposed to benzene, toluene and xylene. The benzene, toluene and xylene concentrations in the air at work places ranged from 0-370, 0-580 and 0-560 mg/cu.m, respectively. It as been stated that the initial period of exposure is characterized by adaptative reactions of neutrophils expressed in increased intracellular activity of acid hydrolases and diminished glycogen reserve. The advanced period of exposure, that is after 55 months of exposure, is associated with some signs of decreased biological deficiency of neutrophils expressed in lowering the activity of selected enzymes and accumulation of both glycogen and lipids. According to the authors opinion the evaluation of the enzymatic content of neutrophils may be helpful in monitoring the toxic effects of benzene and its homologues in industrial workers.
对106名职业性接触苯、甲苯和二甲苯的工人进行了外周血中性粒细胞的组织化学研究。工作场所空气中苯、甲苯和二甲苯的浓度分别为0 - 370毫克/立方米、0 - 580毫克/立方米和0 - 560毫克/立方米。据称，接触初期的特征是中性粒细胞的适应性反应，表现为酸性水解酶的细胞内活性增加和糖原储备减少。接触后期，即接触55个月后，与中性粒细胞生物活性降低的一些迹象有关，表现为某些酶的活性降低以及糖原和脂质的积累。作者认为，评估中性粒细胞的酶含量可能有助于监测工业工人中苯及其同系物的毒性作用。
