Moszczyński P, Lisiewicz J
Folia Haematol Int Mag Klin Morphol Blutforsch. 1983;110(6):948-54.
The activity of acid phosphatase (AP) in peripheral blood lymphocytes was determined by means of histochemical method in 108 workers having occupational contact with organic solvents containing benzene and its homologues. Benzene, toluene and xylene concentrations in the air at work stands were equal to 0-370, 0-580 and 0-560 mg/eu.m., respectively. A progressing reduction of numbers of lymphocytes having AP-positive intact lysosomes was stated in workers with a working time equal 31-122 months. This phenomenon was more expressed in workers exposed to greater concentrations of benzene and its homologues. The damage to the lysosomal apparatus of lymphocytes reflected by an increased permeability of lysosomal membranes can be regarded as one of the earliest symptoms of toxic effects of benzene, toluene and xylene on cells of the lymphocytic series.
采用组织化学方法测定了108名职业接触含苯及其同系物有机溶剂工人外周血淋巴细胞中酸性磷酸酶（AP）的活性。工作场所空气中苯、甲苯和二甲苯的浓度分别为0 - 370、0 - 580和0 - 560毫克/立方米。工作时间为31 - 122个月的工人中，具有AP阳性完整溶酶体的淋巴细胞数量呈逐渐减少趋势。这种现象在接触更高浓度苯及其同系物的工人中表现得更为明显。溶酶体膜通透性增加所反映的淋巴细胞溶酶体装置损伤，可被视为苯、甲苯和二甲苯对淋巴细胞系列细胞毒性作用的最早症状之一。
