15-氢过氧花生四烯酸诱导豚鼠气道高反应性及肺β-肾上腺素能受体数量减少
Induction in guinea-pigs of airway hyperreactivity and decreased lung beta-adrenoceptor number by 15-hydroperoxy-arachidonic acid.
作者信息
Folkerts G, Nijkamp F P, van Oosterhout A J
出版信息
Br J Pharmacol. 1983 Dec;80(4):597-9. doi: 10.1111/j.1476-5381.1983.tb10047.x.
Abstract
Administration to guinea-pigs of 15-hydroperoxy-arachidonic acid (0.2 mg kg-1 i.p.) caused a 20% reduction of lung beta-adrenoceptor number. Furthermore, in vivo, a hyperreactivity of the airways to nebulized histamine was observed. In contrast, administration of 15-hydroxy-arachidonic acid (0.2 mg kg-1 i.p.) did not cause a significant change in either of these parameters.
摘要
给豚鼠腹腔注射15-氢过氧花生四烯酸（0.2毫克/千克）导致肺β-肾上腺素能受体数量减少20%。此外，在体内观察到气道对雾化组胺的高反应性。相比之下，腹腔注射15-羟基花生四烯酸（0.2毫克/千克）并未使这些参数中的任何一个发生显著变化。
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