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1
Effect of desamino-cholecystokinin-octapeptide (CCK-7) on the intraluminal pressure and myoelectrical activity of the gall-bladder, stomach, and small intestine in conscious dogs.去氨基胆囊收缩素八肽（CCK - 7）对清醒犬胆囊、胃和小肠腔内压力及肌电活动的影响。
Br J Pharmacol. 1983 Dec;80(4):681-9. doi: 10.1111/j.1476-5381.1983.tb10058.x.
2
Responses of guinea-pig gastric, ileal and gall bladder smooth muscle to desamino-cholecystokinin-octapeptide (CCK 7).豚鼠胃、回肠和胆囊平滑肌对去氨基胆囊收缩素八肽（CCK 7）的反应。
Methods Find Exp Clin Pharmacol. 1988 Aug;10(8):513-20.
3
Mode of action of cholecystokinin octapeptide on smooth muscles of stomach, ileum and gall bladder.胆囊收缩素八肽对胃、回肠和胆囊平滑肌的作用方式。
Methods Find Exp Clin Pharmacol. 1986 Dec;8(12):697-703.
4
Suc-Tyr(SE)-Met-Gly-Trp-Met-Asp-beta-phenethylamide(410): a competitive antagonist of cholecystokinin-induced contractions in smooth muscles in vitro.苏氨酸-酪氨酸（琥珀酰亚胺酯）-甲硫氨酸-甘氨酸-色氨酸-甲硫氨酸-天冬氨酸-β-苯乙酰胺（410）：一种体外平滑肌中胆囊收缩素诱导收缩的竞争性拮抗剂。
Methods Find Exp Clin Pharmacol. 1987 Jul;9(7):429-35.
5
Endogenous CCK is not involved in the regulation of interdigestive gastrointestinal and gallbladder motility in conscious dogs.内源性胆囊收缩素不参与清醒犬消化间期胃肠及胆囊运动的调节。
Regul Pept. 1992 Oct 13;41(3):249-56. doi: 10.1016/0167-0115(92)90118-e.
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Somatostatin inhibits cholecystokinin-induced contraction of isolated gallbladder smooth muscle cells.生长抑素抑制胆囊收缩素诱导的离体胆囊平滑肌细胞收缩。
J Surg Res. 1995 Dec;59(6):743-6. doi: 10.1006/jsre.1995.1233.
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9
Cholecystokinin and cholinergic agents on periodic gallbladder contraction in dogs.胆囊收缩素和胆碱能药物对犬胆囊周期性收缩的影响
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10
Effects of cholecystokinin-octapeptide on gastric motility of anesthetized dogs.胆囊收缩素八肽对麻醉犬胃动力的影响。
Am J Physiol. 1986 Nov;251(5 Pt 1):G678-81. doi: 10.1152/ajpgi.1986.251.5.G678.

本文引用的文献

1
CHOLECYSTOKININ-PANCREOZYMIN EXTRACTS AND GASTRIC MOTOR INHIBITION.胆囊收缩素-促胰酶素提取物与胃运动抑制
Surg Gynecol Obstet. 1965 Sep;121:557-62.
2
[ENTEROKINETIC ACTION OF CECEKIN].[西泽金的肠动作用]
Arch Mal Appar Dig Mal Nutr. 1964 May;53:607-8.
3
The gastrointestinal hormones, secretin and cholecystokinin-pancreozymin.胃肠激素，即促胰液素和缩胆囊素-促胰酶素。
Ann Intern Med. 1961 Sep;55:395-405. doi: 10.7326/0003-4819-55-3-395.
4
Effect of secretin and cholecystokinin-pancreozymin extracts on gastric motility in man.促胰液素和缩胆囊素-促胰酶素提取物对人体胃动力的影响。
Gut. 1966 Feb;7(1):52-7. doi: 10.1136/gut.7.1.52.
5
[A method for recording biopotentials from the muscles of the stomach in cats with chronic implanted electrodes].[一种利用慢性植入电极记录猫胃肌肉生物电位的方法]
Izv Inst Fiziol (Sofiia). 1965;9:187-91.
6
[Technic for accelerating passage through the small intestine].[加速通过小肠的技术]
Arch Mal Appar Dig Mal Nutr. 1965 Dec;54(12):1285-90.
7
Structure of porcine cholecystokinin-pancreozymin. 1. Cleavage with thrombin and with trypsin.猪胆囊收缩素-促胰酶素的结构。1. 用凝血酶和胰蛋白酶进行切割。
Eur J Biochem. 1968 Oct 17;6(1):156-62. doi: 10.1111/j.1432-1033.1968.tb00433.x.
8
Comparison of effects of gastrin, cholecystokinin-pancreozymin, secretin, and glucagon on human stomach muscle in vitro.胃泌素、缩胆囊素-促胰酶素、促胰液素和胰高血糖素对人胃肌的体外作用比较
Gastroenterology. 1970 Oct;59(4):539-45.
9
Effect of secretin and cholecystokinin on gastric emptying and gastric secretion in man.促胰液素和缩胆囊素对人体胃排空及胃液分泌的影响。
Gastroenterology. 1970 Jun;58(6):820-7.
10
[Use of cholecystokinin in radiologic diagnosis].[胆囊收缩素在放射学诊断中的应用]
Radiologe. 1970 Jan;10(1):36-9.

去氨基胆囊收缩素八肽（CCK - 7）对清醒犬胆囊、胃和小肠腔内压力及肌电活动的影响。

Effect of desamino-cholecystokinin-octapeptide (CCK-7) on the intraluminal pressure and myoelectrical activity of the gall-bladder, stomach, and small intestine in conscious dogs.

作者信息

Milenov E, Nieber K, Niedrich H, Oehme P, Vogt W E

出版信息

Br J Pharmacol. 1983 Dec;80(4):681-9. doi: 10.1111/j.1476-5381.1983.tb10058.x.

DOI:10.1111/j.1476-5381.1983.tb10058.x
PMID:6100845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2045047/
Abstract

Desamino-cholecystokinin-octapeptide (CCK-7) increased the gall-bladder pressure and decreased the gastric pressure following i.v. infusion in conscious dogs. In small intestine and Heidenhain pouch CCK-7 exerted an initial excitatory effect followed by an inhibitory effect on intraluminal pressure and peristalsis. In all organs the effect of CCK-7 on pressure was correlated with a change of spike discharge. CCK-7 is more potent on gastrointestinal motor activity than a Boots preparation of pancreozymin. The results suggest that CCK-7 at doses within the physiological range could be involved in the regulation of gastrointestinal motility.

摘要

去氨基胆囊收缩素八肽（CCK - 7）静脉注射给清醒犬后，可升高胆囊压力并降低胃内压力。在小肠和海登海因小胃中，CCK - 7最初产生兴奋作用，随后对腔内压力和蠕动产生抑制作用。在所有器官中，CCK - 7对压力的影响与锋电位发放的变化相关。CCK - 7对胃肠运动活性的作用比一种胰酶泌素的布茨制剂更强。结果表明，生理范围内剂量的CCK - 7可能参与胃肠动力的调节。