去氨基胆囊收缩素八肽（CCK - 7）对清醒犬胆囊、胃和小肠腔内压力及肌电活动的影响。
Effect of desamino-cholecystokinin-octapeptide (CCK-7) on the intraluminal pressure and myoelectrical activity of the gall-bladder, stomach, and small intestine in conscious dogs.
作者信息
Milenov E, Nieber K, Niedrich H, Oehme P, Vogt W E
出版信息
Br J Pharmacol. 1983 Dec;80(4):681-9. doi: 10.1111/j.1476-5381.1983.tb10058.x.
Desamino-cholecystokinin-octapeptide (CCK-7) increased the gall-bladder pressure and decreased the gastric pressure following i.v. infusion in conscious dogs. In small intestine and Heidenhain pouch CCK-7 exerted an initial excitatory effect followed by an inhibitory effect on intraluminal pressure and peristalsis. In all organs the effect of CCK-7 on pressure was correlated with a change of spike discharge. CCK-7 is more potent on gastrointestinal motor activity than a Boots preparation of pancreozymin. The results suggest that CCK-7 at doses within the physiological range could be involved in the regulation of gastrointestinal motility.
去氨基胆囊收缩素八肽（CCK - 7）静脉注射给清醒犬后，可升高胆囊压力并降低胃内压力。在小肠和海登海因小胃中，CCK - 7最初产生兴奋作用，随后对腔内压力和蠕动产生抑制作用。在所有器官中，CCK - 7对压力的影响与锋电位发放的变化相关。CCK - 7对胃肠运动活性的作用比一种胰酶泌素的布茨制剂更强。结果表明，生理范围内剂量的CCK - 7可能参与胃肠动力的调节。
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