Suzuki T, Takahashi I, Itoh Z
Peptides. 1981;2 Suppl 2:229-33. doi: 10.1016/0196-9781(81)90036-x.
Intravenous infusion of motilin (0.3-0.9 micrograms/kg-hr) during the interdigestive state induced a transient but strong tonic contraction in the gallbladder, which was similar to the natural interdigestive gallbladder contraction, as well as a typical IMC in the stomach and the duodenum. This motilin-induced contraction always occurred simultaneously with the intitiation of phase II contractions of the IMC in the duodenum. The increase in contractile force (11.5 +/- 0.57 g) was not related to the dose of motilin tested. In contrast, intravenous infusion of CCK-octapeptide (CCK-OP, 0.03-0.09 micrograms/kg-hr) induced a dose related tonic contraction (7.8 +/- 0.41-17-7 +/- 0.77 g) which lasted as long as the CCK-OP infusion continued during the interdigestive state. Atropine sulfate (0.025 mg/kg) strongly inhibited both motilin- and CCK-OP induced gallbladder contractions. The present study indicates that the canine gallbladder in the conscious state is responsive to at least two hormonal factors, motilin and CCK. The contractile response of the gallbladder to motilin is quite different from the response to CCK-OP. However, both responses are mediated at least partially by cholinergic pathways.
在消化间期静脉输注胃动素（0.3 - 0.9微克/千克·小时）可诱发胆囊短暂但强烈的强直性收缩，这与自然消化间期胆囊收缩相似，同时也会在胃和十二指肠诱发典型的移行性复合运动（IMC）。这种胃动素诱发的收缩总是与十二指肠IMC的II期收缩起始同时发生。收缩力的增加（11.5±0.57克）与所测试的胃动素剂量无关。相比之下，静脉输注八肽胆囊收缩素（CCK - OP，0.03 - 0.09微克/千克·小时）可诱发剂量相关的强直性收缩（7.8±0.41 - 17.7±0.77克），在消化间期只要持续输注CCK - OP，这种收缩就会持续。硫酸阿托品（0.025毫克/千克）强烈抑制胃动素和CCK - OP诱发的胆囊收缩。本研究表明，清醒状态下犬的胆囊对至少两种激素因子，即胃动素和CCK有反应。胆囊对胃动素的收缩反应与对CCK - OP的反应有很大不同。然而，两种反应至少部分是由胆碱能途径介导的。
