Kuwahara A, Ozawa K, Yanaihara N
Am J Physiol. 1986 Nov;251(5 Pt 1):G678-81. doi: 10.1152/ajpgi.1986.251.5.G678.
The present experiments examined the local effects of cholecystokinin-octapeptide (CCK-8) and related peptides on gastric motility of anesthetized dogs. Peptides were injected through the gastroepiploic artery at doses of 1.0, 2.5, 5.0, 10.0, and 20.0 ng/ml. CCK-8 and its analogues (Glt-CCK-8, pGlu-CCK-8, and Suc1-MePhe8-CCK-7) increased gastric smooth muscle contraction in a dose-dependent manner. ED50 of CCK-8 was 2.97 +/- 0.63 ng/ml. Administration of atropine (100-200 micrograms/kg) inhibited the effects of both CCK-8 and pentagastrin; however, hexamethonium (5 mg/kg) failed to block the contractile response induced by CCK-8 and pentagastrin. These results indicate that CCK-8 and related peptides can act as local modulators in controlling the neural regulation of gastric motility.
本实验研究了胆囊收缩素八肽（CCK-8）及相关肽对麻醉犬胃动力的局部作用。肽通过胃网膜动脉以1.0、2.5、5.0、10.0和20.0 ng/ml的剂量注射。CCK-8及其类似物（Glt-CCK-8、pGlu-CCK-8和Suc1-MePhe8-CCK-7）以剂量依赖性方式增加胃平滑肌收缩。CCK-8的半数有效剂量（ED50）为2.97±0.63 ng/ml。给予阿托品（100 - 200微克/千克）可抑制CCK-8和五肽胃泌素的作用；然而，六甲铵（5毫克/千克）未能阻断CCK-8和五肽胃泌素诱导的收缩反应。这些结果表明，CCK-8及相关肽可作为局部调节剂来控制胃动力的神经调节。
