日本结节病的长期随访

Long-term follow-up in sarcoidosis in Japan.

作者信息

Yamamoto M, Kosuda T, Yanagawa H, Tachibana T, Shima K, Hosoda Y, Mikami R, Homma H

出版信息

Z Erkr Atmungsorgane. 1977 Aug;149(2):191-6.

Abstract

The clinical course of 775 sarcoidosis cases in Japan collected by the Japan Sarcoidosis Committee was followed up in the 6th month, 1st, 2nd, 3rd, 4th-6th, 7th-9th and 10th year and over after the first discovery. The means follow-up period was 5.5 years. The accumulated rates of disappearance of BHL, lung, eye, and whole sarcoidosis lesions calculated by life-table method were 63%, 56%, 59% and 48% respectively at the 1st year, 75% 67%, 71% and 59% respectively at the 2nd year, 79%, 71%, 76% and 64% respectively at the 3rd year, 82%, 74%, 81% and 67% respectively at the 4th-6th year. Judging from the accumulated rates mentioned above, the speakers defined the course of the disease as "good" when the whole sarcoidosis lesions cleared within 2 years. It was revealed that out of 25 factors examined, factors such as "age under 29", "no eye lesions" and "without complaints" at the time of first discovery, were significantly useful for pre-dieting the "good" results. The disappearance of BHL within 6 months was one of the most important indices predicting the "good" outcome of sarcoidosis.

摘要

日本结节病委员会收集的775例结节病患者的临床病程，在首次发现后的第6个月、第1年、第2年、第3年、第4 - 6年、第7 - 9年以及第10年及以后进行了随访。平均随访期为5.5年。采用寿命表法计算的双侧肺门淋巴结肿大（BHL）、肺部、眼部及全身结节病病变消失的累积率，在第1年分别为63%、56%、59%和48%，在第2年分别为75%、67%、71%和59%，在第3年分别为79%、71%、76%和64%，在第4 - 6年分别为82%、74%、81%和67%。根据上述累积率，报告人将疾病病程定义为“良好”，即全身结节病病变在2年内清除。结果显示，在检查的25个因素中，首次发现时“年龄在29岁以下”“无眼部病变”和“无主诉”等因素，对预测“良好”结果具有显著意义。6个月内双侧肺门淋巴结肿大消失是预测结节病“良好”转归的最重要指标之一。