Ruggiero R A, Dosne Pasqualini C
Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
Rev Argent Microbiol. 1983;15(2):119-30.
The relationship between immunodepression and leukemogenesis induced by a murine retro-virus. PLLV-T2, was studied in different strains of mice. Cellular immunity, using as parameters both allograft rejection and graft versus host reaction, was not affected during the early phase of leukemia development. As for humoral immunity, determined by the response to xenogeneic red blood cells and to lipopolysaccharides, no direct relationship between the immunodepression caused by the retrovirus and leukemogenesis could be encountered: in certain strains, such as DBA/2, with susceptibility to leukemogenesis similar to that of BALB/c, no decrease in the immune response was registered during the early phase of the disease. The results obtained demonstrate that immunodepression is not a necessary condition for the clinical appearance of this viral-induced leukemia indicating that humoral and/or cellular immunity would not play an important role as surveillance mechanism against this neoplasia.
研究了小鼠逆转录病毒PLLV-T2诱导的免疫抑制与白血病发生之间的关系，该研究在不同品系的小鼠中进行。以同种异体移植排斥和移植物抗宿主反应作为参数的细胞免疫，在白血病发展的早期阶段未受影响。至于通过对异种红细胞和脂多糖的反应来确定的体液免疫，未发现逆转录病毒引起的免疫抑制与白血病发生之间存在直接关系：在某些品系中，如DBA/2，其白血病易感性与BALB/c相似，在疾病早期未观察到免疫反应降低。所得结果表明，免疫抑制不是这种病毒诱导的白血病临床表现的必要条件，这表明体液和/或细胞免疫作为针对这种肿瘤的监测机制不会发挥重要作用。
