Minning C A, Davidorf F H, Makley T A, Bruce R A
Department of Ophthalmology, Ohio State University, Columbus.
Retina. 1982;2(4):223-30.
This article describes the seventh published case of metastatic carcinoid to the choroid. Only two prior cases have been treated conservatively, one using chemotherapy and the other using photocoagulation and proton beam irradiation. Our patient was unique since she was the first to have conservative therapy by implantation of a radon ring. Initial results were clinically promising, although repeated ultrasound testing actually showed minimal decrease in tumor size. Subsequently, a large retinal detachment caused marked visual deterioration. Persistent pain from neovascular glaucoma prompted later enucleation, and silver staining as well as electron microscopic studies were performed on the choroidal lesion. It was found that the radon ring had little histologic effect on the viability of the tumor cells. This contrasted with an earlier report of the successful treatment of two much smaller choroidal lesions, using external proton beam irradiation. From our pathologic evaluation, we believe that the metastatic carcinoid tumor should be considered relatively radioresistant.
本文描述了第七例已发表的脉络膜转移性类癌病例。之前仅有两例采用保守治疗，一例使用化疗，另一例使用光凝和质子束照射。我们的患者很独特，因为她是首例通过植入氡环进行保守治疗的。尽管重复超声检查实际显示肿瘤大小仅有极小的减小，但初始结果在临床上很有前景。随后，一次大的视网膜脱离导致视力显著下降。新生血管性青光眼引起的持续疼痛促使后来进行了眼球摘除，并对脉络膜病变进行了银染色以及电子显微镜研究。发现氡环对肿瘤细胞的活力几乎没有组织学影响。这与早期关于使用外部质子束照射成功治疗两个小得多的脉络膜病变的报告形成对比。根据我们的病理评估，我们认为转移性类癌肿瘤应被视为相对抗辐射。
