Drüeke T, Fauchet M, Fleury J, Lesourd P, Toure Y, Le Pailleur C, de Vernejoul P, Crosnier J
Lancet. 1980 Jan 19;1(8160):112-4. doi: 10.1016/s0140-6736(80)90602-9.
The effect of parathyroidectomy on left-ventricular function was evaluated in chronic-haemodialysis patients with advanced hyperparathyroidism. Radionuclide angiocardiography (22 patients) and ultrasound echography (8 patients) revealed a significant increase in left-ventricular ejection fraction 1--2 weeks after parathyroidectomy. This improvement was associated with an augmented cardiac index (radionuclide method) and with an increase in mean velocity of circumferential myocardial fibre shortening (echocardiography). Circulating blood volume and erythrocyte space, as well as arterial blood-pressure, had changed little after parathyroidectomy, whereas plasma calcium, phosphate, and immunoreactive parathyroid hormone were significantly lower after surgery. Thus, correction of severe hyperparathyroidism led to a significant improvement in cardiac performance.
在患有晚期甲状旁腺功能亢进的慢性血液透析患者中，评估了甲状旁腺切除对左心室功能的影响。放射性核素血管造影术（22例患者）和超声心动图检查（8例患者）显示，甲状旁腺切除术后1至2周，左心室射血分数显著增加。这种改善与心脏指数增加（放射性核素法）以及圆周心肌纤维缩短平均速度增加（超声心动图）相关。甲状旁腺切除术后，循环血容量、红细胞容积以及动脉血压变化不大，而术后血浆钙、磷酸盐和免疫反应性甲状旁腺激素显著降低。因此，纠正严重的甲状旁腺功能亢进导致心脏功能显著改善。
