β-内啡肽对人体的深度镇痛作用。
Profound analgesic effects of beta-endorphin in man.
作者信息
Oyama T, Jin T, Yamaya R, Ling N, Guillemin R
出版信息
Lancet. 1980 Jan 19;1(8160):122-4. doi: 10.1016/s0140-6736(80)90606-6.
PMID:6101459
Abstract
Profound and long-lasting analgesia (mean duration of pain relief 33.4 h, range 22.5--73.5 h) was produced by intrathecal administration of 3 mg synthetic beta-endorphin in all of 14 patients with intractable pain due to disseminated cancer. No respiratory depression, hypotension, hypothermia, or catatonia was observed.
摘要
对14例因播散性癌症导致顽固性疼痛的患者鞘内注射3毫克合成β-内啡肽，均产生了深度且持久的镇痛效果（平均疼痛缓解持续时间为33.4小时，范围为22.5 - 73.5小时）。未观察到呼吸抑制、低血压、体温过低或紧张症。
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