Pickar D, Dubois M, Cohen M R
Am J Psychiatry. 1984 Jan;141(1):103-4. doi: 10.1176/ajp.141.1.103.
A patient with a disseminated malignancy received 3 mg of synthetic beta-endorphin administered intrathecally by lumbar puncture. A marked behavioral syndrome characterized by confusion, hypomanic/manic behavior, and psychosis followed drug administration and persisted for more than 2 days.