Follett E A, Barr A, Crawford R J, Mitchell R
Lancet. 1980 Feb 2;1(8162):246-9. doi: 10.1016/s0140-6736(80)90729-1.
Selected blood donors, antenatal patients, and hospital patients with a history of jaundice were investigated for evidence of prio exposure to hepatitis A and B viruses. Two markers of hepatitis B-infection were sought--surface antibody (anti-HBs) and core antibody (anti-HBc). The prevalence of both markers was low in jaundice history donors and antenatal patients and was no different from the prevalence in random populations of both groups. In contrast, the prevalence of antibody to hepatitis A-virus (anti-HAV) was very much higher in donors and antenatal patients with a history of jaundice than in random groups of the same age and ethnic origin. Similarly, hospital patients with a history of jaundice showed a very low prevalence of prior hepatitis-B infection and a very high prevalence of prior hepatitis-A infection. The findings suggest that in a country with a low incidence of hepatitis-B carriage a history of jaundice is much more likely to equate with prior hepatitis-A infection than B infection. There is no evidence to support the practice of regarding blood donors or patients with a history of jaundice as a special group with more prior exposure to hepatitis-B virus and thus more likelihood of being long-term carriers of hepatitis-B virus.
对选定的献血者、产前患者以及有黄疸病史的住院患者进行了调查，以寻找既往接触甲型和乙型肝炎病毒的证据。研究了两种乙型肝炎感染标志物——表面抗体（抗-HBs）和核心抗体（抗-HBc）。在有黄疸病史的献血者和产前患者中，这两种标志物的流行率都很低，与两组随机人群的流行率没有差异。相比之下，有黄疸病史的献血者和产前患者中甲型肝炎病毒抗体（抗-HAV）的流行率比同年龄和同种族的随机组要高得多。同样，有黄疸病史的住院患者既往感染乙型肝炎的流行率很低，而既往感染甲型肝炎的流行率很高。研究结果表明，在乙型肝炎携带率较低的国家，有黄疸病史更有可能意味着既往感染甲型肝炎而非乙型肝炎。没有证据支持将有黄疸病史的献血者或患者视为既往接触乙型肝炎病毒更多、因此更有可能成为乙型肝炎病毒长期携带者的特殊群体的做法。
