Neuberger J, Portmann B, Nunnerley H B, Laws J W, Davis M, Williams R
Lancet. 1980 Feb 9;1(8163):273-6. doi: 10.1016/s0140-6736(80)90776-x.
Seven of ten women with oral-contraceptive-associated liver tumours were found to have hepatocellular carcinoma. The diagnosis was often delayed, although hepatomegaly was always present on examination, and liver-function tests and erythrocyte sedimentation-rates were abnormal in most cases. Other investigations, including routine technetium liver scans and biopsy, were sometimes misleading. There were important differences in alpha-fetoprotein concentration, vascularity on angiography, and survival between liver tumours in pill users and non-users.
在患有口服避孕药相关肝肿瘤的10名女性中，有7名被发现患有肝细胞癌。尽管检查时总是存在肝肿大，且大多数病例的肝功能检查和红细胞沉降率异常，但诊断往往延迟。包括常规锝肝扫描和活检在内的其他检查有时会产生误导。口服避孕药使用者和非使用者的肝肿瘤在甲胎蛋白浓度、血管造影显示的血管分布以及生存率方面存在重要差异。
