Evans E B, Pollock T M, Cradock-Watson J E, Ridehalgh M K
Lancet. 1980 Feb 16;1(8164):354-6. doi: 10.1016/s0140-6736(80)90897-1.
Human anti-chickenpox immunoglobulin (zoster immune globulin, ZIG) was largely ineffective in preventing infection in forty-three high-risk contacts of chickenpox. Twenty-nine of these non-immune infants and children who had been in close contact with cases of varicella became infected, and symptoms developed in twenty-four. Since ZIG may modify chickenpox it should continue to be given to high-risk contacts until the availability of a simple and sensitive test makes it possible to identify those who are susceptible. However, ZIG is not necesary for infants whose mothers have chickenpox or zoster five or more days before delivery, since all such infants (eleven) had varicella-zoster antibody at birth.
人抗水痘免疫球蛋白（带状疱疹免疫球蛋白，ZIG）在预防43例水痘高危接触者感染方面基本无效。这些与水痘患者密切接触的29名非免疫婴幼儿被感染，其中24人出现症状。由于ZIG可能改变水痘病情，在有简单灵敏的检测方法能够识别易感者之前，仍应继续给予高危接触者ZIG。然而，对于母亲在分娩前5天或更早患水痘或带状疱疹的婴儿，ZIG并非必需，因为所有此类婴儿（11名）出生时均有水痘-带状疱疹抗体。
