Rampen F H, Mulder J H
Lancet. 1980 Mar 15;1(8168 Pt 1):562-4. doi: 10.1016/s0140-6736(80)91055-7.
Of 688 melanoma patients registered during 1956--78, 267 developed metastatic spread of the disease. Sex differences in the course of the disease in this subset were studied. Intervals between subsequent stages of melanoma activity were longer, but not significantly so, in female than male patients. Survival times from initial distant metastasis were significantly longer in women than in men. Tumour doubling time of pulmonary secondaries revealed a clear tendency to a slower growth rate in female patients. Our analysis suggests that malignant melanoma might be an androgen-dependent tumour. Therapy with anti-androgens or orchidectomy deserves consideration in male patients with metastatic melanoma.
在1956年至1978年登记的688例黑色素瘤患者中，有267例发生了疾病的转移扩散。对该亚组患者疾病进程中的性别差异进行了研究。黑色素瘤活动后续阶段之间的间隔在女性患者中比男性患者更长，但差异不显著。从初始远处转移开始计算的生存时间，女性明显长于男性。肺转移瘤的肿瘤倍增时间显示，女性患者的生长速度有明显减缓的趋势。我们的分析表明，恶性黑色素瘤可能是一种雄激素依赖性肿瘤。对于转移性黑色素瘤男性患者，抗雄激素治疗或睾丸切除术值得考虑。
