Rudolf H, Göretzlehner G, Brügmann E, Töwe J, Rudolf K
Zentralbl Gynakol. 1977;99(25):1548-53.
Indocyaningreen (ICG) was given for the characterize of the excretion function of the liver during the course of normal pregnancy, sub partu and post partum. Studies were performed in 168 primi- and multigravidas with normal medical and obstetric histories (mean age of 23,5 years). 0,5 mg ICG/kg body mass were injected intravenously as a bolus. 18 healthy nonpregnant women served as controls (mean age of 24,2 years). In the I. and II. trimester of pregnancy the elimination of ICG was not decreased in comparison to the controls (3,64 +/- 0,86). The increased retention of ICG in the 40th week of pregnancy (4,67 +/- 0,41) and during labor (7,02 +/- 2,32) are caused through the physiological alterations of pregnancy. No placental transfer of the dye could be detected by simultaneous measurement of ICG in the maternal and fetal cord blood. During the post partum period the elimination of ICG will be normal. ICG is recommend instead of Bromsulfaleine (BSP) for the estimation of excretion function of the liver during pregnancy and childbed.
在正常妊娠、分娩期和产后过程中，给予吲哚菁绿（ICG）以评估肝脏的排泄功能。对168例有正常内科和产科病史的初产妇和经产妇进行了研究（平均年龄23.5岁）。以0.5mg ICG/kg体重静脉推注给药。18名健康非孕妇作为对照（平均年龄24.2岁）。在妊娠的第一和第二孕期，与对照组相比，ICG的清除率没有降低（3.64±0.86）。妊娠第40周（4.67±0.41）和分娩期间（7.02±2.32）ICG潴留增加是由妊娠的生理改变引起的。通过同时测量母血和胎儿脐血中的ICG，未检测到染料的胎盘转运。产后期间，ICG的清除率将恢复正常。推荐使用ICG代替磺溴酞钠（BSP）来评估妊娠和产褥期肝脏的排泄功能。
