牛脑微血管中的神经递质受体结合
Neurotransmitter receptor binding in bovine cerebral microvessels.
作者信息
Peroutka S J, Moskowitz M A, Reinhard J F, Snyder S H
出版信息
Science. 1980 May 9;208(4444):610-2. doi: 10.1126/science.6102801.
PMID:6102801
Abstract
Purified preparations of microvessels from bovine cerebral cortex contain substantial levels of alpha-adrenergic, beta-adrenergic, and histamine 1 receptor binding sites but only negligible serotonin, muscarinic cholinergic, opiate, and benzodiazepine receptor binding. Norepinephrine and histamine may be endogenous regulators of the cerebral microcirculation at the observed receptors.
摘要
从牛大脑皮层纯化得到的微血管制剂含有大量的α-肾上腺素能、β-肾上腺素能和组胺1受体结合位点，但5-羟色胺、毒蕈碱胆碱能、阿片类和苯二氮䓬受体结合量可忽略不计。去甲肾上腺素和组胺可能是在观察到的受体处脑微循环的内源性调节因子。
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