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人血清科恩IV组分（富含α球蛋白[球蛋白校正]）可抑制人脑神经递质受体处的配体结合。

Human serum Cohn fraction IV (alpha-globulin [correction of globin] enriched) inhibits ligand binding at neurotransmitter receptors in human brain.

作者信息

Andorn A C, Pappolla M A, Fox H, Klemens F K, Martello P A

出版信息

Proc Natl Acad Sci U S A. 1986 Jun;83(12):4572-5. doi: 10.1073/pnas.83.12.4572.

DOI:10.1073/pnas.83.12.4572
PMID:3012573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC323777/
Abstract

Human serum proteins are found in significant density in the neuropil in brains of demented individuals. The functional significance of these abnormally distributed proteins has been unknown. We now report that alpha-globulin-enriched fractions of human serum decrease the specific binding of [3H]spiroperidol at its binding sites in postmortem human frontal cortex and caudate. The substances in this serum fraction apparently exert their effect by a direct action on the binding site. Since [3H]spiroperidol labels serotoninergic and dopaminergic among other neurotransmitter receptors, these results suggest that components of human serum inhibit the binding of ligands at neurotransmitter receptors.

摘要

在痴呆症患者大脑的神经毡中发现了高密度的人血清蛋白。这些异常分布蛋白的功能意义尚不清楚。我们现在报告，人血清中富含α-球蛋白的组分可降低[3H]螺哌啶醇在死后人类额叶皮质和尾状核中其结合位点的特异性结合。该血清组分中的物质显然通过对结合位点的直接作用发挥其效应。由于[3H]螺哌啶醇除了标记其他神经递质受体外还标记5-羟色胺能和多巴胺能受体，这些结果表明人血清成分可抑制神经递质受体处配体的结合。

相似文献

1
Human serum Cohn fraction IV (alpha-globulin [correction of globin] enriched) inhibits ligand binding at neurotransmitter receptors in human brain.人血清科恩IV组分（富含α球蛋白[球蛋白校正]）可抑制人脑神经递质受体处的配体结合。
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4572-5. doi: 10.1073/pnas.83.12.4572.
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本文引用的文献

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Discrimination of multiple [3H]5-hydroxytryptamine binding sites by the neuroleptic spiperone in rat brain.抗精神病药螺哌隆对大鼠脑中多个[3H]5-羟色胺结合位点的鉴别
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Determination of selective and nonselective compounds for the 5-HT 1A and 5-HT 1B receptor subtypes in rat frontal cortex.大鼠额叶皮质中5-羟色胺1A和5-羟色胺1B受体亚型的选择性和非选择性化合物的测定。
J Pharmacol Exp Ther. 1984 Dec;231(3):480-7.
10
Effect of age on human brain serotonin (S-1) binding sites.年龄对人脑海马5-羟色胺（S-1）结合位点的影响。
J Neurochem. 1984 Dec;43(6):1699-705. doi: 10.1111/j.1471-4159.1984.tb06098.x.

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