Stern R S, Zierler S, Parrish J A
Lancet. 1980 Apr 5;1(8171):732-5. doi: 10.1016/s0140-6736(80)91231-3.
A case-control study, consisting of 59 skin cancer patients with severe psoriasis, was conducted to evaluate the effect of treatment with tar and/or artificial ultraviolet radiation on the risk of developing cutaneous carcinoma. Using 924 unmatched controls, we estimated that the crude rate of skin cancer was 2.4-fold for patients with high exposure to tar and ultraviolet radiation, compared with those lacking high exposure. Using a control series of 126 patients matched for age, skin type, region of residence, sex, history of exposure to ionising radiation, and number of 8-methoxypsoralen photochemotherapy treatments, we observed a stronger association (relative rate = 4.7, 95% confidence limits = 2.2 to 10.0). The magnitude of the relative rates argues for continued surveillance for tumours among patients with psoriasis who receive long-term tar or artificial ultraviolet radiation therapy.
一项病例对照研究纳入了59例患有严重银屑病的皮肤癌患者，旨在评估焦油和/或人工紫外线辐射治疗对发生皮肤癌风险的影响。我们以924名未匹配的对照者为参照，估计与未大量接触焦油和紫外线辐射的患者相比，大量接触此类物质的患者患皮肤癌的粗发病率高2.4倍。在另一组由126名年龄、皮肤类型、居住地区、性别、电离辐射接触史及8-甲氧基补骨脂素光化学疗法治疗次数相匹配的对照者组成的队列中，我们观察到了更强的关联（相对发病率=4.7，95%置信区间=2.2至10.0）。相对发病率的大小表明，对于接受长期焦油或人工紫外线辐射治疗的银屑病患者，有必要持续监测其肿瘤发生情况。
