Zhu Baohua, Jing Mingyi, Yu Qianying, Ge Xiaopei, Yuan Fan, Shi Lanhui
Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Surgery of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Postepy Dermatol Alergol. 2022 Jun;39(3):460-471. doi: 10.5114/ada.2021.108445. Epub 2021 Aug 16.
Psoriasis is a genetic chronic disease mediated by the immune system with systemic and cutaneous manifestations that can significantly deteriorate patients' quality of life. Two-three percent of the population worldwide suffer from psoriasis and it imposes a substantial economic burden on patients. The aetiology is mainly related with genes and environmental factors. The pathophysiology of psoriasis is characterized by T cells and dendritic cells, antimicrobial peptides, genetic predispositions, lipoprotein-2, galactosin-3, fractalkine, vaspin, and human neutrophilic peptides, etc. in the progression of psoriasis. For patients with psoriasis, the traditional treatments include corticosteroids, vitamin D analogues, calcineurin inhibitors, methotrexate, cyclosporine, acitretin, phototherapy, and biological agents, etc. Nanodermatology is an emerging, multidisciplinary science that is gaining increasing recognition in the treatment of psoriasis. This review provides a summary of the pathophysiology, epidemiology, clinical diagnosis, and classical pharmacotherapy of psoriasis. The review also summarizes different nanotechnology therapies for effective treatment of psoriasis.
银屑病是一种由免疫系统介导的遗传性慢性疾病，具有全身和皮肤表现，可显著降低患者的生活质量。全球2%-3%的人口患有银屑病，给患者带来了沉重的经济负担。其病因主要与基因和环境因素有关。银屑病的病理生理学特征在于T细胞和树突状细胞、抗菌肽、遗传易感性、脂蛋白-2、半乳凝素-3、趋化因子、内脏脂肪素和人嗜中性粒细胞肽等在银屑病进展过程中的作用。对于银屑病患者，传统治疗方法包括皮质类固醇、维生素D类似物、钙调神经磷酸酶抑制剂、甲氨蝶呤、环孢素、阿维A、光疗和生物制剂等。纳米皮肤病学是一门新兴的多学科科学，在银屑病治疗中越来越受到认可。本文综述了银屑病的病理生理学、流行病学、临床诊断和经典药物治疗方法。同时，本文还总结了不同的纳米技术疗法在有效治疗银屑病方面的应用。
