Kampmann J P, Johansen K, Hansen J M, Helweg J
Lancet. 1980 Apr 5;1(8171):736-7. doi: 10.1016/s0140-6736(80)91233-7.
Propylthiouracil (PTU) concentrations were measured in blood and milk from nine lactating women after oral administration of 400 mg of PTU. 1 1/2 h after PTU ingestion mean serum-PTU reached 7.7 microgram/ml and the mean concentration of PTU in milk reached only 0.7 microgram/ml. The mean total amount of PTU excreted during 4 h was 99 microgram--i.e., 0.025% of the administered dose. One of the suckling babies was studied for 5 months during which the mother received 200-300 mg of PTU daily: there were no changes in any of the thyroid parameters. PTU is not concentrated in human breast milk and recommended dosages to the mother result in minimal and presumably clinically insignificant doses to the suckling infant.
对9名哺乳期妇女口服400毫克丙硫氧嘧啶（PTU）后，检测其血液和乳汁中的PTU浓度。摄入PTU 1.5小时后，血清PTU平均浓度达到7.7微克/毫升，而乳汁中PTU的平均浓度仅为0.7微克/毫升。4小时内排出的PTU平均总量为99微克，即给药剂量的0.025%。对其中一名哺乳婴儿进行了5个月的研究，在此期间母亲每天服用200 - 300毫克PTU：婴儿的任何甲状腺参数均无变化。PTU不会在人乳中浓缩，给母亲推荐的剂量对哺乳婴儿造成的剂量极小，可能在临床上无显著意义。
