Hendler N, Cimini C, Ma T, Long D
Am J Psychiatry. 1980 Jul;137(7):828-30. doi: 10.1176/ajp.137.7.828.
In an attempt to determine the source of cognitive impairment in 106 consecutively admitted patients at the Johns Hopkins Chronic Pain Treatment Center, EEG, the Wechsler Adult Intelligence Scale, Memory Quotient, and Bender Gestalt tests were administered. Patients receiving benzodiazepines alone demonstrated alterations in cognitive functioning and EEG evidence of a sedative effect. Patients receiving narcotics alone and a group of patients not receiving medication did not show signs of cognitive impairment. The effects of benzodiazepines on sleep and perception of chronic pain, in combination with the cortical changes that they produce, imply that these drugs should not be used in most patients with chronic pain.
为了确定约翰·霍普金斯慢性疼痛治疗中心连续收治的106例患者认知障碍的根源，对他们进行了脑电图、韦氏成人智力量表、记忆商数及本德视觉运动格式塔测验。仅接受苯二氮䓬类药物治疗的患者出现了认知功能改变以及脑电图显示的镇静作用证据。仅接受麻醉药治疗的患者及一组未接受药物治疗的患者未表现出认知障碍迹象。苯二氮䓬类药物对睡眠及慢性疼痛感知的影响，再加上它们所产生的皮质变化，意味着这些药物不适用于大多数慢性疼痛患者。
