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Characterization of dog hepatic drug-metabolizing enzymes and resultant effects on benzo[a]pyrene metabolite pattern and mutagenicity.

作者信息

Golan M D, Bücker M, Schmassmann H U, Raphael D, Jung R, Bindel U, Brase H O, Tegtmeyer F, Friedberg T, Lorenz J, Stasiecki P, Oesch F

出版信息

Drug Metab Dispos. 1980 May-Jun;8(3):121-6.

PMID:6104571
Abstract
摘要

相似文献

1
Characterization of dog hepatic drug-metabolizing enzymes and resultant effects on benzo[a]pyrene metabolite pattern and mutagenicity.犬肝脏药物代谢酶的特性及其对苯并[a]芘代谢产物模式和致突变性的影响
Drug Metab Dispos. 1980 May-Jun;8(3):121-6.
2
Benzo(a)pyrene metabolism by rat liver microsomes: effects of adding purified glutathione S-transferases A, B, and C.大鼠肝脏微粒体对苯并(a)芘的代谢:添加纯化的谷胱甘肽S-转移酶A、B和C的影响。
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Structural requirements for the metabolic activation of benzo[a]pyrene to mutagenic products: effects of modifications in the 4,5-, 7,8-, and 9,10-positions.苯并[a]芘代谢活化为诱变产物的结构要求:4,5-、7,8-和9,10-位修饰的影响
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Modification of benzo(a)pyrene metabolism in hepatic microsomes from untreated and induced rats by imidazole derivatives which inhibit monooxygenase activity and enhance epoxide hydrolase activity.咪唑衍生物对未处理和诱导大鼠肝微粒体中苯并(a)芘代谢的影响,该衍生物抑制单加氧酶活性并增强环氧化物水解酶活性。
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Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.通过高度纯化的肝微粒体酶将苯并(a)芘和苯并(a)芘衍生物代谢为致突变产物。
J Biol Chem. 1976 Aug 25;251(16):4882-90.
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Comparative benzo[a]pyrene metabolite patterns in fish and rodents.鱼类和啮齿动物中苯并[a]芘代谢物模式的比较
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Correlation between the kinetic parameters of the microsomal benzo(a)pyrene hydroxylase and the mutagenicity of benzo(a)pyrene in vitro [proceedings].微粒体苯并(a)芘羟化酶动力学参数与苯并(a)芘体外诱变性的相关性[会议论文集]
Arch Int Physiol Biochim. 1978 May;86(2):447-8.

引用本文的文献

1
Purification and characterization of a new cytosolic glutathione S-transferase (glutathione S-transferase X) from rat liver.从大鼠肝脏中纯化和鉴定一种新的胞质谷胱甘肽S-转移酶(谷胱甘肽S-转移酶X)。
Biochem J. 1983 Dec 1;215(3):617-25. doi: 10.1042/bj2150617.