急性和慢性给予拟胆碱缩瞳药物后，人眼原位虹膜括约肌对胆碱能受体刺激的敏感性降低。
Subsensitivity to cholinoceptor stimulation of the human iris sphincter in situ following acute and chronic administration of cholinomimetic miotic drugs.
作者信息
Smith S A, Smith S E
出版信息
Br J Pharmacol. 1980 Jul;69(3):513-8. doi: 10.1111/j.1476-5381.1980.tb07042.x.
1 Maximal pupillary miosis was obtained with single topical applications of 4 cholinomimetic drugs in therapeutic concentrations to normal human subjects. 2 When the pupil had recovered from the miosis, there remained a reduced light reflex response of 22.7% at 24 h after aceclidine, 18.0% at 31 h after pilocarpine, 10.3% at 48 h after physostigmine and 4.9% at 7 h after arecoline. 3 This reduced sensitivity to light was accompanied by an overshoot of the resting pupil diameter and, after aceclidine miosis, a reduced response to a second application of miotic. 4 Similar findings were observed in glaucoma patients following withdrawal of chronic pilocarpine therapy. 5 It is suggested that the slowly reversible after-effects of acute and chronic administration of cholinomimetic miotics can be explained by desensitization of iris sphincter cholinoceptors.
- 对正常人类受试者单次局部应用治疗浓度的4种拟胆碱药物可使瞳孔最大限度地缩小。2. 当瞳孔从缩瞳状态恢复后，醋甲胆碱作用24小时后光反射反应降低22.7%，毛果芸香碱作用31小时后降低18.0%，毒扁豆碱作用48小时后降低10.3%，槟榔碱作用7小时后降低4.9%。3. 这种对光的敏感性降低伴随着静息瞳孔直径的过度增大，并且在醋甲胆碱缩瞳后，对第二次应用缩瞳剂的反应降低。4. 在青光眼患者停用慢性毛果芸香碱治疗后也观察到了类似的结果。5. 有人提出，急性和慢性应用拟胆碱缩瞳剂后缓慢可逆的后遗症可以用虹膜括约肌胆碱受体脱敏来解释。
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