通过将毛果芸香碱以油剂形式应用，其对瞳孔的作用增强。
An increased effect of pilocarpine on the pupil by application of the drug in oil.
作者信息
Smith S A, Smith S E, Lazare R
出版信息
Br J Ophthalmol. 1978 May;62(5):314-7. doi: 10.1136/bjo.62.5.314.
Abstract
In healthy volunteers pilocarpine in an oily solution had a greater degree and duration of effect on the pupil than the same amount of drug given in aqueous solution. Blue- and brown-eyed subjects had similar degrees of miosis, but the time taken to reach peak effects was longer with the latter. It can be concluded that eye drops made with an oily solvent may provide an improvement in the treatment of glaucoma with pilocarpine.
摘要
在健康志愿者中，油性溶液中的毛果芸香碱对瞳孔的作用程度和持续时间比相同剂量的水溶液给药更大。蓝眼睛和棕眼睛的受试者瞳孔缩小程度相似，但后者达到最大效应所需的时间更长。可以得出结论，用油性溶剂制成的眼药水可能会改善毛果芸香碱治疗青光眼的效果。
相似文献
1
An increased effect of pilocarpine on the pupil by application of the drug in oil.通过将毛果芸香碱以油剂形式应用，其对瞳孔的作用增强。
Br J Ophthalmol. 1978 May;62(5):314-7. doi: 10.1136/bjo.62.5.314.
2
Effect of vehicle on pilocarpine-induced miosis.
Acta Ophthalmol (Copenh). 1978;56(4):496-503. doi: 10.1111/j.1755-3768.1978.tb01362.x.
3
Pupillary response to four concentrations of pilocarpine in normal subjects: application to testing for Adie tonic pupil.正常受试者对四种浓度毛果芸香碱的瞳孔反应：应用于阿狄强直性瞳孔检测
Am J Ophthalmol. 2002 Mar;133(3):333-6. doi: 10.1016/s0002-9394(01)01420-9.
4
Effects of topical administration of 2.0% pilocarpine on intraocular pressure and pupil size in cats.局部应用2.0%毛果芸香碱对猫眼压和瞳孔大小的影响。
Am J Vet Res. 1991 Mar;52(3):441-4.
5
[Action of miosis of 1% pilocarpine liposome in rabbits].[1%毛果芸香碱脂质体对家兔的缩瞳作用]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Jun;25(3):343-5.
6
The additive miotic effects of dapiprazole and pilocarpine.达哌唑与毛果芸香碱的相加缩瞳作用。
Graefes Arch Clin Exp Ophthalmol. 1995 Jul;233(7):448-51. doi: 10.1007/BF00180951.
7
Temporal Effects of 2% Pilocarpine Ophthalmic Solution on Human Pupil Size and Accommodation.2%毛果芸香碱眼药水对人瞳孔大小和调节功能的时间效应
Mil Med. 2020 Jan 7;185(Suppl 1):435-442. doi: 10.1093/milmed/usz235.
8
[Effect of different concentrations and vehicles on pilocarpine miosis. II. Different vehicles].
Klin Monbl Augenheilkd. 1973 Jul;163(1):51-6.
9
[Reaction of the pupil in patients with glaucoma following long-time treatment with pilocarpine].[毛果芸香碱长期治疗后青光眼患者瞳孔的反应]
Vestn Oftalmol. 1979 Jul-Aug(4):8-10.
10
The use of pilocarpine eye drops for estimating the time since death.使用毛果芸香碱滴眼液估计死亡时间。
J Forensic Leg Med. 2016 Apr;39:100-3. doi: 10.1016/j.jflm.2016.01.008. Epub 2016 Jan 21.
引用本文的文献
1
Standards in Pupillography.瞳孔测量标准。
Front Neurol. 2019 Feb 22;10:129. doi: 10.3389/fneur.2019.00129. eCollection 2019.
2
A pharmacological method for measuring the penetration of topical mydriatic drugs in man.一种测量局部散瞳药物在人体中渗透情况的药理学方法。
Br J Clin Pharmacol. 1982 Sep;14(3):468-9. doi: 10.1111/j.1365-2125.1982.tb02014.x.
3
Evidence for a neuropathic aetiology in the small pupil of diabetes mellitus.糖尿病小瞳孔中神经病变病因的证据。
Br J Ophthalmol. 1983 Feb;67(2):89-93. doi: 10.1136/bjo.67.2.89.
4
Prolonged pulse-entry of pilocarpine with a soluble drug insert.
Graefes Arch Clin Exp Ophthalmol. 1983;221(2):96-9. doi: 10.1007/BF02133815.
5
Subsensitivity to cholinoceptor stimulation of the human iris sphincter in situ following acute and chronic administration of cholinomimetic miotic drugs.急性和慢性给予拟胆碱缩瞳药物后，人眼原位虹膜括约肌对胆碱能受体刺激的敏感性降低。
Br J Pharmacol. 1980 Jul;69(3):513-8. doi: 10.1111/j.1476-5381.1980.tb07042.x.
6
Relative bioavailability of pilocarpine from a novel ophthalmic delivery system and conventional eyedrop formulations.新型眼用给药系统与传统滴眼剂制剂中毛果芸香碱的相对生物利用度。
Br J Ophthalmol. 1989 May;73(5):360-2. doi: 10.1136/bjo.73.5.360.
7
A comparison of the ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops in normal human volunteers.0.025%溴隐亭滴眼液与0.25%噻吗洛尔滴眼液对正常人类志愿者的降眼压效果比较。
Br J Clin Pharmacol. 1989 Oct;28(4):443-7. doi: 10.1111/j.1365-2125.1989.tb03525.x.
8
Eyedrop instillation for reluctant children.给不配合的儿童滴眼药水
Br J Ophthalmol. 1991 Aug;75(8):480-1. doi: 10.1136/bjo.75.8.480.
9
Management of acute closed-angle glaucoma with miotics and timolol.用缩瞳剂和噻吗洛尔治疗急性闭角型青光眼
Br J Ophthalmol. 1979 Dec;63(12):822-5. doi: 10.1136/bjo.63.12.822.
10
Comparison of the pupillary, refractive, and hypotensive effects of Ocusert-40 and pilocarpine eyedrops in the treatment of chronic simple glaucoma.Ocusert-40与毛果芸香碱滴眼液治疗慢性单纯性青光眼的瞳孔、屈光及降压效果比较。
Br J Ophthalmol. 1979 Apr;63(4):228-32. doi: 10.1136/bjo.63.4.228.
本文引用的文献
1
Electronic pupillography; a new instrument and some clinical applications.
AMA Arch Ophthalmol. 1958 Mar;59(3):352-63.
2
A comparative study of mydriatic and cycloplegic agents; in human subjects without eye disease.散瞳药与睫状肌麻痹药的对比研究；针对无眼部疾病的人类受试者。
Am J Ophthalmol. 1957 Nov;44(5 Pt 1):617-22. doi: 10.1016/0002-9394(57)90266-0.
3
Role of the vehicle in local treatment of the eye.载体在眼部局部治疗中的作用。
Acta Ophthalmol (Copenh). 1964;42(4):727-34. doi: 10.1111/j.1755-3768.1964.tb01724.x.
4
Response to mydriatics in the African.非洲人对散瞳剂的反应。
Br J Ophthalmol. 1971 Aug;55(8):538-43. doi: 10.1136/bjo.55.8.538.
5
Factors influencing patient noncompliance: a theoretical approach.影响患者不依从性的因素：一种理论方法。
Nurs Res. 1971 Nov-Dec;20(6):509-16.
6
Effect of ocular pigmentation on hypotensive response to pilocarpine.
Am J Ophthalmol. 1971 Nov;72(5):923-5. doi: 10.1016/0002-9394(71)91689-8.
7
Drop size and initial dosing frequency problems of topically applied ophthalmic drugs.局部应用眼科药物的液滴大小和初始给药频率问题。
J Pharm Sci. 1974 Mar;63(3):333-8. doi: 10.1002/jps.2600630304.
8
[Effect of different concentrations and vehicles on pilocarpine miosis. II. Different vehicles].
Klin Monbl Augenheilkd. 1973 Jul;163(1):51-6.
9
Iris pigmentation and atropine mydriasis.虹膜色素沉着与阿托品散瞳
J Pharmacol Exp Ther. 1976 Apr;197(1):79-88.
10
Pilocarpine levels in the eyes of rabbits following topical application.
Exp Eye Res. 1975 Sep;21(3):281-7. doi: 10.1016/0014-4835(75)90099-8.
Zotero 插件