• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

肝脏疾病中血清鸟嘌呤酶的评估。

Evaluation of serum guanase in hepatic diseases.

作者信息

Kuzmits R, Seyfried H, Wolf A, Müller M M

出版信息

Enzyme. 1980;25(3):148-52. doi: 10.1159/000459240.

DOI:10.1159/000459240
PMID:6105073
Abstract

Serum guanase activity was measured in 20 healthy adults and in 62 patients with acute viral hepatitis, chronic active hepatitis, chronic persistent hepatitis, liver cirrhosis and fatty liver. Guanase and gamma-GT in patients were elevated in 87 and 64%, respectively. Elevated guanase activities were found in most cases of acute viral hepatitis, as well as in chronic hepatopathies. In patients with acute viral hepatitis pathologic activities of guanase were found following partial or total normalization of other liver function tests.

摘要

对20名健康成年人以及62名患有急性病毒性肝炎、慢性活动性肝炎、慢性持续性肝炎、肝硬化和脂肪肝的患者进行了血清鸟嘌呤酶活性检测。患者中鸟嘌呤酶和γ-谷氨酰转移酶升高的比例分别为87%和64%。在大多数急性病毒性肝炎病例以及慢性肝病病例中均发现鸟嘌呤酶活性升高。在急性病毒性肝炎患者中,在其他肝功能检查部分或完全恢复正常后仍发现鸟嘌呤酶的病理活性。

相似文献

1
Evaluation of serum guanase in hepatic diseases.肝脏疾病中血清鸟嘌呤酶的评估。
Enzyme. 1980;25(3):148-52. doi: 10.1159/000459240.
2
Clinical significance of serum guanase activity in various liver diseases.血清鸟嘌呤酶活性在各种肝脏疾病中的临床意义。
Jpn J Med. 1989 Jan-Feb;28(1):22-4. doi: 10.2169/internalmedicine1962.28.22.
3
Clinical evaluation of serum guanase activity in liver diseases.肝脏疾病中血清鸟嘌呤酶活性的临床评估
Clin Biochem. 1984 Oct;17(5):327-30. doi: 10.1016/s0009-9120(84)90661-1.
4
[Clinical application of serum guanase analysis by electrophoresis].[血清鸟嘌呤酶电泳分析的临床应用]
Rinsho Byori. 1988 Nov;36(11):1313-6.
5
Serum gamma-glutamyl transpeptidase: its clinical significance.血清γ-谷氨酰转肽酶:其临床意义
Acta Med Acad Sci Hung. 1976;33(4):309-19.
6
Activation energy, relative substrate specificity and optimum pH of guanase from humanrat, mouse and guinea pig sera and tissues.
Enzyme. 1975;20(2):90-7. doi: 10.1159/000458924.
7
Serum guanase in diagnosis of hepatic disease.血清鸟嘌呤酶在肝病诊断中的应用
S Afr Med J. 1970 May 30;44(22):639-41.
8
Further observations on the properties of serum and tissue guanase from man and some animal species. Optimum pH and activation energy in the presence of 8-azaguanine.关于人和某些动物血清及组织鸟嘌呤酶性质的进一步观察。8-氮杂鸟嘌呤存在时的最适pH值和活化能。
Enzyme. 1976;21(4):342-8. doi: 10.1159/000458877.
9
Serum guanase activities after myocardial infarction.心肌梗死后的血清鸟嘌呤酶活性。
Clin Chim Acta. 1975 Sep 1;63(2):205-10. doi: 10.1016/0009-8981(75)90164-3.
10
Clinical evaluation of measurement of serum guanase activity as a screening test of liver damage.血清鸟嘌呤酶活性测定作为肝损伤筛查试验的临床评估
Gastroenterol Jpn. 1981;16(5):478-92. doi: 10.1007/BF02774520.

引用本文的文献

1
Characterization of Xenopus laevis guanine deaminase reveals new insights for its expression and function in the embryonic kidney.爪蟾鸟嘌呤脱氨酶的特性研究为其在胚胎肾中的表达和功能提供了新的见解。
Dev Dyn. 2019 Apr;248(4):296-305. doi: 10.1002/dvdy.14. Epub 2019 Feb 19.
2
Biochemical Characterization of Adenine Deaminase and Guanine Deaminase and Their Potential Application in Lowering Purine Content in Beer.腺嘌呤脱氨酶和鸟嘌呤脱氨酶的生化特性及其在降低啤酒中嘌呤含量的潜在应用
Front Bioeng Biotechnol. 2018 Nov 29;6:180. doi: 10.3389/fbioe.2018.00180. eCollection 2018.
3
Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: synthesis, biochemical screening, and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines.
异氮杂卓霉素类似物作为鸟嘌呤酶的潜在过渡态类似物抑制剂:各种取代的咪唑并[4,5-e][1,4]二氮杂环庚烷的合成、生化筛选和构效关系研究。
Bioorg Med Chem. 2013 Sep 1;21(17):4893-903. doi: 10.1016/j.bmc.2013.06.069. Epub 2013 Jul 11.
4
Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine.鉴定与鸟嘌呤脱氨酶(cypin)结合亲和力高于鸟嘌呤的小分子化合物。
Bioorg Med Chem. 2010 Sep 15;18(18):6748-55. doi: 10.1016/j.bmc.2010.07.054. Epub 2010 Jul 27.
5
Guanine deaminase functions as dihydropterin deaminase in the biosynthesis of aurodrosopterin, a minor red eye pigment of Drosophila.在果蝇一种次要的红色眼色素金蝶蝶呤的生物合成过程中,鸟嘌呤脱氨酶作为二氢蝶呤脱氨酶发挥作用。
J Biol Chem. 2009 Aug 28;284(35):23426-35. doi: 10.1074/jbc.M109.016493. Epub 2009 Jun 30.