Zucker大鼠中的过氧化物酶体棕榈酰辅酶A氧化
Peroxisomal palmitoyl-CoA oxidation in the Zucker rat.
作者信息
Brady P S, Hoppel C L
出版信息
Biochem J. 1983 Jun 15;212(3):891-4. doi: 10.1042/bj2120891.
Abstract
The effects of 3 or 6 days of starvation on hepatic peroxisomal palmitoyl-CoA oxidation were examined in adult lean and obese Zucker rats. When expressed either per mg of DNA or per total liver, obese rats had almost 2-fold higher oxidation rates than the lean rats. Within 6 days of starvation rates fell by 50% among both phenotypes. When data were expressed per 100 g body wt., lean and obese rats had similar rates, falling from a mean of 0.57 to 0.28 mumol/min per 100 g body wt. within 6 days of starvation. Peroxisomal oxidative changes paralleled mitochondrial beta-oxidative changes.
摘要
在成年瘦型和肥胖型 Zucker 大鼠中，研究了 3 天或 6 天饥饿对肝脏过氧化物酶体棕榈酰辅酶 A 氧化的影响。以每毫克 DNA 或全肝计算时，肥胖大鼠的氧化速率几乎是瘦型大鼠的 2 倍。在饥饿 6 天内，两种表型的氧化速率均下降了 50%。以每 100 克体重计算数据时，瘦型和肥胖型大鼠的氧化速率相似，在饥饿 6 天内从平均每 100 克体重 0.57 微摩尔/分钟降至 0.28 微摩尔/分钟。过氧化物酶体氧化变化与线粒体β氧化变化平行。
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