Tabor E, Aronson D L, Gerety R J
Lancet. 1980 Jul 12;2(8185):68-70. doi: 10.1016/s0140-6736(80)92942-6.
Hepatitis-B-virus infectivity can be removed from a heat-labile clotting factor concentrate by the addition of hepatitis-B immune-globulin. Three chimpanzees were each inoculated with samples of factor-IX complex (factor IX) which had been deliberately contaminated with 10(3.5) chimpanzee infectious doses of hepatitis-B virus from a known infectious inoculum. Two of these factor IX samples had been incubated with hepatitis-B immune-globulin after the addition of hepatitis-B virus. 10 weeks after inoculation hepatitis-B infection developed in the chimpanzee inoculated with untreated factor IX. Hepatitis B did not develop in the two which received treated factor IX; no serloigical evidence of hepatitis B could be detected during 52 weeks of evaluation.
通过添加乙肝免疫球蛋白，可以从对热不稳定的凝血因子浓缩物中去除乙肝病毒传染性。三只黑猩猩分别接种了故意被来自已知感染性接种物的10(3.5)个黑猩猩感染剂量的乙肝病毒污染的凝血因子IX复合物（凝血因子IX）样本。其中两个凝血因子IX样本在添加乙肝病毒后与乙肝免疫球蛋白一起孵育。接种未处理的凝血因子IX的黑猩猩在接种10周后发生了乙肝感染。接受处理过的凝血因子IX的两只黑猩猩未发生乙肝感染；在52周的评估期间未检测到乙肝的血清学证据。
