Sheppard M C, Shapiro B, Hudson A, Pimstone B L
Horm Metab Res. 1980;12(6):236-9. doi: 10.1055/s-2007-996256.
Tissue and serum somatostatin levels were measured in genetically lean and obese Zucker rats. Immunoreactive somatostatin content was decreased in three central nervous system regions (hypothalamus, septum and preoptic area and thalamus) of obese rats but was increased in cerebral cortex. No differences were observed in antral or colonic somatostatin content but obese animals had significantly elevated pancreatic levels. Portal vein somatostatin-like immunoreactivity in contrast was significantly lower in obese rats. The widespread alterations in tissue and serum somatostatin-like immunoreactivity suggest either a diffuse abnormality of somatostatin physiology or a response to a generalised feature of the obese hyperinsulinaemic state.
对遗传性瘦型和肥胖型 Zucker 大鼠的组织和血清生长抑素水平进行了测量。肥胖大鼠的三个中枢神经系统区域（下丘脑、隔区、视前区和丘脑）中免疫反应性生长抑素含量降低，但大脑皮层中的含量增加。胃窦或结肠生长抑素含量未观察到差异，但肥胖动物的胰腺水平显著升高。相比之下，肥胖大鼠门静脉中生长抑素样免疫反应性显著降低。组织和血清中生长抑素样免疫反应性的广泛改变表明，要么是生长抑素生理学存在弥漫性异常，要么是对肥胖高胰岛素血症状态的一般特征的一种反应。
